Results 71 to 80 of about 3,812,995 (305)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
The Big Burp: A Bad Day in the Paleocene [PDF]
This lesson focuses on global warming and a possible connection with the Paleocene extinction event. Students will explore how a global warming episode associated with the release of methane from methane hydrate deposits could have been responsible for ...
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Political media and political globalization Convergence and correlation
الأستاذ, 2018 The present world is witnessing strong structural indicators that reflect the interrelationship between political media and political globalization.
Dr. Haitham Nima Rahim Al - Azzawi
doaj +1 more source
This lesson on the cause of currents and water circulation in the Arctic Ocean will require students to investigate the influence of salinity and temperature on the density of seawater to determine what factors drive water circulation in the Arctic Ocean.
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Legal Education Unbundled (and Rebundled) [PDF]
, 2019 This essay calls for an unbundling of legal education, much like the kind of unbundling we have seen in the cable, music, and print news media. It suggests that the standard legal education bundle -the generalized JD-is just one of many forms of legal ...
Carpenter, Megan
core +1 more source
Would You Like a Sample? [PDF]
In this lesson students will investigate sampling strategies for biological communities in the ocean to see how well biological samples represent the actual communities from which they are taken.
core +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Informatization of Education. Media Education and Media Literacy
Main Issues Of Pedagogy And Psychology, 2021 Recent studies have shown that education in the 21st century cannot be imagined without using information and communication technologies, digital and media tools. As a result of teachers’ training, it has become clear that there is a need to promote teachers, ICTs, media education and media literacy. The article presents the informatization of ...
openaire +2 more sources
Roots of the Hawaiian Hotspot [PDF]
In this lesson students will investigate the seismology and geological origins of the Hawaiian Islands to discover how scientists can obtain information on geological processes deep within the Earth. As a result of this activity, students will be able to
Mel Goodwin
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