Results 121 to 130 of about 8,368,619 (264)

Effective doses of nalmefene for prevention of sufentanil-induced cough during induction of general anesthesia in children

Zhongguo linchuang yanjiu
Objective To determine the median effective dose(ED50)and 95% effective dose(ED95)of namefene hydrochloride in inhibiting sufentanil-induced cough(SIC)during induction of general anesthesia in children.Methods Thirty-five children［aged 1-6 years, 29 ...
XU Zhijun, JIA Jian
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Antivenoms: potency or median effective dose, which to use?

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
V Morais, S Ifran, P Berasain, H Massaldi   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Median Effective Volume of 0.25% Ropivacaine for Bilateral Transversus Thoracis Muscle Plane Block in Patients Undergoing Open Cardiac Surgery [PDF]

Jiaying Sun,1,2,* Chufan Liu,1,* Xinlian Gong,1 Ruoxing Chen,1 Shikang Deng,3 Yujun Zha,1 Shijie Ji,1 Zhousheng Jin,1 Hongfei Chen1 1Department of Pain Management, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang ...
Deng S, Ji S, Zha Y, Liu C, Chen H, Chen R, Jin Z, Sun J, Gong X   +8 more
core  

Learning from the Prevention and Early Intervention Initiative in Ireland [PDF]

, 2016
Centre for Effective Services (CES)
core   +6 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effective Dose Calculation in Critical Patients: A Comparative Analysis between Monte Carlo simulations and coefficient calculations

reservedIntroduzione: La tomografia computerizzata (TC) è una tecnica di imaging diagnostico; tuttavia, comporta un'esposizione significativa a radiazioni ionizzanti, rendendo necessaria una stima accurata della dose per garantire la sicurezza del ...
KANSO, ISSAM
core  

Establishing the Median and 95% Effective Doses of Oliceridine for Immediate Post-Surgical Analgesia Following Laparoscopic Cholecystectomy: A Double-Blind, Sequential Dose-Finding Study [PDF]

Xianghua Cao,1,2,* Huiling Xiao,1,2,* Haoran Yan,1,2,* Yujiao Wei,1,2 Qiting Wen,1,2 Zhijian Zhang,1,2 Guizhen Xu,1,2 Binbin Xu,1,2 Jian Chen,1,2 Xueping Li1,2 1Department of Anesthesiology, Dongguan Tungwah Hospital, Dongguan, People’s ...
Li X, Cao X, Zhang Z, Chen J, Xu B, Xiao H, Wen Q, Yan H, Wei Y, Xu G   +9 more
core