Results 111 to 120 of about 8,368,619 (264)
Modified repeated median filters [PDF]
We discuss moving window techniques for fast extraction of a signal comprising monotonic trends and abrupt shifts from a noisy time series with irrelevant spikes.
Fried, Roland +3 more
core
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Centre for Effective Services: strategy 2012 – 2014 and beyond [PDF]
, 2012 The Centre for Effective Services (CES) was established in 2008 in the Republic of Ireland, and in 2010 in Northern Ireland. The overall remit of the centre was to provide technical and organisational ‘expertise’ to promote and support the application of
Centre for Effective Services
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Axiomatic characterization of the absolute median on cube-free median networks [PDF]
In Vohra, European J. Operational Research 90 (1996) 78 – 84, a characterization of the absolute median of a tree network using three simple axioms is presented. This note extends that result from tree networks to cube-free median networks.
Mulder, H.M., Vohra, R.V.
core
Significantly low effective dose from 18FDG PET/CT scans using dose reducing strategies: lesser is better [PDF]
, 2016 BACKGROUND: Fluorodeoxyglucose (18FDG) PET/CT imaging has become an important component of the management paradigm in oncology. However, the significant imparted radiation exposure is a matter of growing concern especially in younger populations who have
Zaman, Unaiza +3 more
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
, 2019 Median of the organ equivalent dose for each protocol by BEIR VII category (male and female) and effective dose (gender neutral).
Richard Fox (153532) +8 more
core +1 more source