Results 91 to 100 of about 697,972 (287)

Efficacy and safety of bortezomib with dexamethasone regimen in elderly newly diagnosed multiple myeloma patients with co-morbidities [PDF]

, 2016
Bortezomib-based induction therapies have shown to increase complete response rates and are used as an upfront therapy for newly diagnosed multiple myeloma patients.
Lee, Saem
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

A new formulation of oral viscous budesonide in treating of paediatric eosinophilic oesophagitis: a pilot study [PDF]

, 2017
OBJECTIVES: Oral viscous budesonide is a recent therapeutic option for eosinophilic oesophagitis (EoE) compared with dietary restriction and inhaled steroids.
Amil, D. J., Cucchiara, S., Isoldi, S., Lucarelli, S., Oliva, S., Papoff, P., Rossetti, D., Rossi, P., Tiberti, A.   +8 more
core   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Safety and Effectiveness of Stoss Therapy in Children with Vitamin D Deficiency [PDF]

, 2020
Objectives: Paediatric vitamin D (25-hydroxyvitamin D - 25OHD) deficiency can lead to nutritional rickets and extra-skeletal complications. Compliance with daily therapy can be difficult, making high dose, short-term vitamin D (stoss) therapy attractive ...
Tannous, Paul
core   +1 more source

Trilostane in dogs [PDF]

, 2010
Over the last 10 years, trilostane, a competitive inhibitor of steroid synthesis, is being widely used for the treatment of canine hyperadrenocorticism.
Alenza, Angles, Baker, Barker, Bell, Benchekroun, Biller, Boag, Braddock, Cerundolo, Chapman, Clemente, Dewis, Dunn, Eastwood, Feldman, Galac, Galac, Golden, Goy-Thollot, Guptill, Hurley, Ian K. Ramsey, Kenefick, Kintzer, Komanicky, Leone, Lorenz, Machida, Mantis, McGee, McGowan, McGrotty, Neiger, Neiger, Neuman, Peterson, Potts, Puddefoot, Ramsey, Ramsey, Randolph, Reusch, Robinson, Ruckstuhl, Semple, Semple, Sieber-Ruckstuhl, Sieber-Ruckstuhl, Skelly, Tebb, Teshima, Tueni, Vaughan, Wenger, Wilbur, Williams, Winterberg, Witt, Zeugswetter   +59 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A phase 3 multicenter, prospective, open-label efficacy and safety study of immune globulin (human) 10% caprylate/chromatography purified in patients with myasthenia gravis exacerbations [PDF]

, 2019
Background: Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular transmission. Exacerbations may involve increasing bulbar weakness and/or sudden respiratory failure, both of which can be critically disabling.
Ayguasanosa, J, Balasa, R, Bril, V, Camprubi, S, Chen, J, De Bleecker, Jan, Garcia, B, Griffin, R, Heckmann, JM, Henriquez, W, Karelis, G, Lagrange, E, Mondou, E, Nicolle, M, Stuchevskaya, T, Van Damme, P, Vilciu, C, Villa, A   +17 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source