Results 81 to 90 of about 8,368,619 (264)

The 50% effective dose of remimazolam combined with different doses of esketamine for painless gastroscopy

Scientific Reports
Objective: Remimazolam is a novel benzodiazepine sedative that provides effective sedation, stable haemodynamics, and minimal adverse effects during intravenous general anaesthesia.
Li Zhao, Xuelei Zhou, Linlin Chen, Wei Mao, Yiping Guo, Xianchun Liu, Longyi Zhang, Ying Xie, Linji Li   +8 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Dose calculations for [¹³¹I] meta-iodobenzylguanidine-induced bystander effects

, 2014
Targeted radiotherapy is a potentially useful treatment for some cancers and may be potentiated by bystander effects. However, without estimation of absorbed dose, it is difficult to compare the effects with conventional external radiation treatment ...
R. J. Mairs, Seymour, C B, M. D. Gow, Mairs, R J, C. B. Seymour, Gow, M.D., Mothersill, C.E., Seymour, C.B., C. E. Mothersill, Mairs, R.J., M. Boyd, W. V. Prestiwch, Mothersill, C E, Prestiwch, W V, Prestiwch, W.V., Boyd, Marie, Boyd, M., Gow, M D   +17 more
core   +1 more source

Dose-response relationships for fever and seroconversion.

, 2021
The dashed and solid horizontal line segments indicate the 95% and 85% bias-corrected and accelerated bootstrap percentile confidence intervals, respectively.
Michael Winpigler (11320759), John Yeager (11320729), Amy L. Reese (11320735), David Clarke (79349), Kim Rhodes (11320753), Tina Sweeney (11320756), Heather Zimmerman (11320765), Brian Holland (11320732), Katie Beck (11320723), Susan Miller (1421617), Ashley Patty (11320750), Artemas Herzog (2155816), Jennifer Biryukov (11320720), Gregory Williams (3319173), Owen Price (451770), Paul A. Dabisch (11320717), Jeremy A. Boydston (11320726), Brian Green (580579), Sherry Rippeon (11320744), Tammy Jenkins (11320741), Emmanuel Manan (11320747), Alec S. Hail (11320768), Victoria Wahl (11320771), Jaleal S. Sanjak (3685258), Jason Rodriguez (11320762), Louis A. Altamura (11218647), Jordan K. Bohannon (5999951), Denise Freeburger (11320738), James Miller (4667866), David Miller (62440), Michael Hevey (2155828)   +30 more
core   +1 more source

ED50 of ciprofol combined with different doses of remifentanil during upper gastrointestinal endoscopy in school-aged children: a prospective dose-finding study using an up-and-down sequential allocation method

Frontiers in Pharmacology
ObjectiveThis study aimed to determine the 50% effective dose (ED50) of ciprofol when combined with different doses of remifentanil for upper gastrointestinal endoscopy of school-age children and to evaluate its safety.MethodsThis study involved school ...
Xu Zhang, Xu Zhang, Ning Zhang, Haicheng Song, Yueyi Ren   +4 more
doaj   +1 more source

Esketamine combined with dexmedetomidine and lidocaine induced inbition of tracheal intubation response [PDF]

Xin yixue
Objective To investigate the median effective dose （ED50） of esketamine for inhibiting tracheal intubation response during the induction of dexmedetomidine combined with lidocaine under opioid-free anesthesia （OFA）.
DENG Dongxiang, WU Duozhi
doaj   +1 more source

Establishment of a therapeutic ratio for Gamma Knife Radiosurgery of trigeminal neuralgia: The critical importance of biologically effective dose (BED) versus physical dose.

World Neurosurgery, 2020
OBJECTIVES How variations of treatment time affect the safety/efficacy of Gamma Knife (GK) radiosurgery is a matter of considerable debate. Due to the relative simplicity of treatment planning for trigeminal neuralgia (TN) this question has been ...
C. Tuleasca, I. Paddick, J. Hopewell, B. Jones, W. T. Millar, H. Hamdi, D. Porcheron, M. Levivier, J. Régis   +8 more
semanticscholar   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A note on nonparametric estimation of the effective dose in quantal bioassay [PDF]

For the common binary response model we propose a direct method for the nonparametric estimation of the effective dose level ED? (0Binary response model,effective dose level,nonparametric regression,isotonic regression,order restricted inference,local ...
Dette, Holger, Neumeyer, Natalie, Pilz, Kay F.   +2 more
core