Results 81 to 90 of about 452,355 (274)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Long term outcome of adolescent and adult patients with pineal parenchymal tumors treated with fractionated radiotherapy between 1982 and 2003 - a single institution's experience [PDF]

, 2010
Background: To evaluate the effectivity of fractionated radiotherapy in adolescent and adult patients with pineal parenchymal tumors (PPT). Methods: Between 1982 and 2003, 14 patients with PPTs were treated with fractionated radiotherapy.
Schulz-Ertner Daniela, Stoiber Eva, Herfarth, Klaus, Klaus Herfarth, Schaible, Benjamin, Debus Jürgen, Daniela Schulz-Ertner, Peter E Huber, Stoiber, Eva Maria, Huber, Peter E., Jürgen Debus, Herfarth Klaus, Susanne Oertel, Schaible Benjamin, Eva Stoiber, Eva Maria Stoiber, Debus, Jürgen, Oertel Susanne, Oertel, Susanne, Benjamin Schaible, Schulz-Ertner, Daniela, Huber Peter E   +21 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effective radiation dose, time, and contrast medium to measure fractional flow reserve [PDF]

, 2010
Objectives This study sought to define the additional effective radiation dose, procedural time, and contrast medium needed to obtain fractional flow reserve (FFR) measurements after a diagnostic coronary angiogram.
Wyffels, Eric, Heyse, A., Vanderheyden, Marc, Van Durme, Frederic, Heyndrickx, Guy R., Marc Vanderheyden, BARBATO, EMANUELE, Heyse, Alex, Guy R. Heyndrickx, Bernard De Bruyne, Muller, O., William Wijns, Mangiacapra, F., Heyndrickx, G. R., Muller, Olivier, Trana, C., Catalina Trana, Frederic Van Durme, Luc Van Driessche, Jozef Bartunek, Wijns, W., De Block, Liesbeth, Bartunek, J., De Jans, J., Argyrios Ntalianis, Van Driessche, Luc, Vanderheyden, M., Mangiacapra, Fabio, De Bruyne, Bernard, Jo De Jans, Wijns, William, Carina De Backer, De Bruyne, B., Emanuele Barbato, Van Driessche, L., Peace, Aaron, Liesbeth De Block, Peace, A., De Backer, C., Eric Wyffels, Wyffels, E., Bartunek, Jozef, Olivier Muller, Aaron Peace, Alex Heyse, Ntalianis, A., De Backer, Carina, De Jans, Jo, Fabio Mangiacapra, Van Durme, F., De Block, L., Ntalianis, Argyrios, Trana, Catalina   +52 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Median Effective Volume of 0.25% Ropivacaine for Bilateral Transversus Thoracis Muscle Plane Block in Patients Undergoing Open Cardiac Surgery [PDF]

Jiaying Sun,1,2,* Chufan Liu,1,* Xinlian Gong,1 Ruoxing Chen,1 Shikang Deng,3 Yujun Zha,1 Shijie Ji,1 Zhousheng Jin,1 Hongfei Chen1 1Department of Pain Management, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang ...
Deng S, Ji S, Zha Y, Liu C, Chen H, Chen R, Jin Z, Sun J, Gong X   +8 more
core   +1 more source

Radiation dose associated with common computed tomography examination [PDF]

, 2017
Objective: To survey computed tomography (CT) radiation dose associated with non-contrast spiral Multislice CT examination in our institute. Methods: Detailed parameters for 362 consecutive examinations, including the patient weight, height, volume CT ...
Sabry El Mogy, Ayman Mokhtar, Maysa Abd El-Hamid, Huda Refaie, Mohamed Elawdy, Tarek A. El-Diasty   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source