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Median effective dose of 0.2% ropivacaine for ultrasound-guided median nerve block in young children
Anaesthesia Critical Care & Pain Medicine, 2023To determine the median effective dose (ED50) and the 95% effective dose (ED95) of 0.2% ropivacaine for ultrasound-guided lower forearm median nerve block in paediatric patients.Eligible children were American Society of Anesthesiologists (ASA) status I-II scheduled to have elective open surgery for trigger thumb repair.
Weiping Wang +10 more
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Regional Anesthesia & Pain Medicine, 2022
Background Although intrathecal ropivacaine has been widely used for caesarean delivery, there are limited data for the use of ropivacaine for prophylactic cervical cerclage. We sought to determine the median effective dose of intrathecal ropivacaine for prophylactic cervical cerclage in 50% of patients (ED50) and ...
Kun Liu +4 more
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Background Although intrathecal ropivacaine has been widely used for caesarean delivery, there are limited data for the use of ropivacaine for prophylactic cervical cerclage. We sought to determine the median effective dose of intrathecal ropivacaine for prophylactic cervical cerclage in 50% of patients (ED50) and ...
Kun Liu +4 more
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Evaluation of statistical methodologies for estimation of median effective dose
Toxicology and Applied Pharmacology, 1985A comparison is made of statistical techniques currently in use for analysis of quantal assay data. The discussion focuses on the choice of the functional model to use in the description of the tolerance distribution for the estimation of the median effective dose and in the contrast between exact and graphical methods of estimation for a given choice ...
S M, Debanne, H S, Haller
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A Nomographic Probit Solution for the Median Effective Dose (ED50)
The Journal of Immunology, 1950Summary A simple and rapid nomographic probit solution for the median effective dose (ED50) is proposed. ED50 and the slope of the dosage-response curve are directly read off from the same nomogram. Additional nomograms convert death rates into probits, and give estimates of the standard error of ED50, the standard error of the slope ...
W, KOCH, D, KAPLAN
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Median Effective Doses (ED50) of Halothane in Adults and Children
Anesthesiology, 1969Median effective doses of halothane (ED50), determined in 73 pediatric subjects and 31 adults grouped according to age, were: 1.20 per cent at 0 to 6 months; 1.16 per cent at 6 to 24 months; 1.07 per cent at 24 to 48 months; and 0.9 per cent in adults. The dose-response curves for all groups did not deviate significantly from parallelism. Halothane was
H F, Nicodemus +3 more
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Median effective dose of isoflurane, sevoflurane, and desflurane in green iguanas
American Journal of Veterinary Research, 2006Abstract Objective—To determine the median effective dose (ED50; equivalent to the minimum alveolar concentration [MAC]) of isoflurane, sevoflurane, and desflurane for anesthesia in iguanas. Animals—6 healthy adult green iguanas. Procedure—In unmedicated iguanas, anesthesia was induced and maintained with each of the 3 volatile drugs administered on ...
Linda S, Barter +4 more
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Interval estimation of the median effective dose for a logistic dose-response curve
Journal of Applied Statistics, 1999In 1986, Williams showed how, assuming a logistic dose-response curve, one can construct a confidence interval for the median effective dose from the asymptotic likelihood ratio test. He gave reasons for preferring this likelihood ratio interval to the established interval calculated by applying Fieller's theorem to the maximum-likelihood estimates ...
Peter Harris +3 more
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Optimal Bayesian Sequential Estimation of the Median Effective Dose
Biometrika, 1970This paper concerns the sequential design of experiments for estimating the median lethal dose parameter of a quantal, logistic dose response curve. Bayesian decision theory is used to provide a stopping rule and terminal decision rule to minimize the prior expectation of the total cost of observation plus estimation loss. Special cases in which trials
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Interpretation of confidence intervals for median effective dose estimates
Environmental Toxicology and Chemistry, 1989Abstract Philosophical considerations in the interpretation of probability can confuse the meaning of interval estimates. Most techniques for calculating interval estimates for the median effective dose (LC50) have been developed under a Neyman-Pearson probability structure, which requires interpretation in terms of asymptotic ...
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