Results 201 to 210 of about 425,006 (219)
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Optimal Bayesian estimation of the median effective dose
Journal of Statistical Planning and Inference, 1988This paper provides some properties of the Fisher information function arising in quantal response bioassay, attribute life testing and dilution assay models. It is shown that the Fisher information function (arising in probit, logit and extreme value models) is a totally positive function of order 2 and consequently unimodal as a function of the ...
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Median effective dose of propofol required for induction of anesthesia in goats
Journal of the American Veterinary Medical Association, 1997Objective— To determine the median effective dose (ED50) of propofol required for induction of anesthesia in goats and the frequency of myoclonic activity and apnea associated with propofol administration. Design— Clinical trial. Animals— 28 healthy mature goats. Procedure— ED50 was determined by use of the up-and-down method.
L S, Pablo, J E, Bailey, J C, Ko
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Misuse of âDeduced Ratiosâ in the Estimation of Median Effective Doses
Nature, 1947Dragstedt and Lang1 wrote: “It seems to us obvious that a rabbit that died from 100 mgm. would have died of any higher dose and one that survived from 150 mgm. per kilogram would have survived from any lesser dose”, and tabulated their “mortality percentages” as deduced according to “this rationale” from experienced ratios at the various doses ...
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The Effect of Massive Doses of Neutrons on the Median Survival Time of Mice
Radiation Research, 1956The median survival time of experimental animals exposed to Xor y-ray dosages ranging from 100 to more than 100,000 r has been determined by a number of investigators (1-8). In general there is excellent agreement as to the shape of the doseresponse curve and as to the fact that this curve shows several distinct segments which may be related to ...
S M, ROTHERMEL +2 more
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VARIOUS METHODS OF INTERVAL ESTIMATION OF THE MEDIAN EFFECTIVE DOSE
Communications in Statistics - Simulation and Computation, 2001The bootstrap, a resampling approach to statistical inference, has been recommended as an alternative to the more traditional parametric approaches. Assuming a logistic dose-response curve, a number of studies have investigated the percentage coverage probabilities of various methods of interval estimation of the median effective dose (ED50).
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Anesthesiology, 2005
Background The study was designed to determine and compare the median effective doses (MEDs) of intrathecal ropivacaine with levobupivacaine for labor analgesia. Methods In this double-blind study, 100 parturients in early labor were randomized to receive either intrathecal ...
Alex T, Sia +3 more
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Background The study was designed to determine and compare the median effective doses (MEDs) of intrathecal ropivacaine with levobupivacaine for labor analgesia. Methods In this double-blind study, 100 parturients in early labor were randomized to receive either intrathecal ...
Alex T, Sia +3 more
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Acta Anaesthesiologica Scandinavica, 2010
Background: The addition of opioid to local anaesthetics has become a well‐accepted practice of spinal anaesthesia for caesarean delivery. Successful caesarean delivery anaesthesia has been reported with the use of a low dose of intrathecal hyperbaric ropivacaine coadministered with sufentanil.
X, Chen, X, Qian, F, Fu, H, Lu, B, Bein
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Background: The addition of opioid to local anaesthetics has become a well‐accepted practice of spinal anaesthesia for caesarean delivery. Successful caesarean delivery anaesthesia has been reported with the use of a low dose of intrathecal hyperbaric ropivacaine coadministered with sufentanil.
X, Chen, X, Qian, F, Fu, H, Lu, B, Bein
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Biometrical Journal, 1999
In this paper the properties of C-optimal designs constructed for estimating the median effective dose within the framework of two-parametric linear logistic models are critically assessed. It is well known that this design criterion which is based on the first-order variance approximation of the exact variance of the maximum likelihood estimate of the
Guiard, Volker, Pichlmeier, Uwe
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In this paper the properties of C-optimal designs constructed for estimating the median effective dose within the framework of two-parametric linear logistic models are critically assessed. It is well known that this design criterion which is based on the first-order variance approximation of the exact variance of the maximum likelihood estimate of the
Guiard, Volker, Pichlmeier, Uwe
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Carcinogenesis, 1980
Experimental dose-effect relationships of carcinogens following either acute (single dose) or chronic (time to tumor) exposure appears to conform with the median-effect principle (Chou, J. Theor. Biol. 59, 253-276, 1976) of the mass-action law: f(a)/ (1 - f(a)) = (D/D(m))m, where D is dose or cumulative dose, D(m) is the D required for the median ...
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Experimental dose-effect relationships of carcinogens following either acute (single dose) or chronic (time to tumor) exposure appears to conform with the median-effect principle (Chou, J. Theor. Biol. 59, 253-276, 1976) of the mass-action law: f(a)/ (1 - f(a)) = (D/D(m))m, where D is dose or cumulative dose, D(m) is the D required for the median ...
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Anesthesia & Analgesia, 2005
Tramadol is a centrally-acting analgesic drug. In a search of an effective balanced analgesia technique with a morphine-sparing component, we studied the median effective analgesic doses (ED(50)) of tramadol, morphine, and their combination to determine the nature of their interaction using an isobolographic analysis.
Thi Aurore, Marcou +3 more
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Tramadol is a centrally-acting analgesic drug. In a search of an effective balanced analgesia technique with a morphine-sparing component, we studied the median effective analgesic doses (ED(50)) of tramadol, morphine, and their combination to determine the nature of their interaction using an isobolographic analysis.
Thi Aurore, Marcou +3 more
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