Results 251 to 260 of about 697,972 (287)
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Anesthesia & Analgesia, 2005
Tramadol is a centrally-acting analgesic drug. In a search of an effective balanced analgesia technique with a morphine-sparing component, we studied the median effective analgesic doses (ED(50)) of tramadol, morphine, and their combination to determine the nature of their interaction using an isobolographic analysis.
Thi Aurore, Marcou +3 more
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Tramadol is a centrally-acting analgesic drug. In a search of an effective balanced analgesia technique with a morphine-sparing component, we studied the median effective analgesic doses (ED(50)) of tramadol, morphine, and their combination to determine the nature of their interaction using an isobolographic analysis.
Thi Aurore, Marcou +3 more
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Optimal Bayesian sequential estimation of the median effective dose
Biometrika, 1970This paper concerns the sequential design of experiments for estimating the median lethal dose parameter of a quantal, logistic dose response curve. Bayesian decision theory is used to provide a stopping rule and terminal decision rule to minimize the prior expectation of the total cost of observation plus estimation loss. Special cases in which trials
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VARIOUS METHODS OF INTERVAL ESTIMATION OF THE MEDIAN EFFECTIVE DOSE
Communications in Statistics - Simulation and Computation, 2001The bootstrap, a resampling approach to statistical inference, has been recommended as an alternative to the more traditional parametric approaches. Assuming a logistic dose-response curve, a number of studies have investigated the percentage coverage probabilities of various methods of interval estimation of the median effective dose (ED50).
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Anesthesia & Analgesia, 2014
In this study, we sought to determine the median effective dose (ED50) for motor block of intrathecally administered plain bupivacaine in adults (20-80 years) and to assess the effect of age on ED50 required for motor block.This study was performed in 129 adult patients undergoing transurethral, urological, or lower limb surgery under combined spinal ...
Mingquan, Chen, Chun, Chen, Qibin, Ke
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In this study, we sought to determine the median effective dose (ED50) for motor block of intrathecally administered plain bupivacaine in adults (20-80 years) and to assess the effect of age on ED50 required for motor block.This study was performed in 129 adult patients undergoing transurethral, urological, or lower limb surgery under combined spinal ...
Mingquan, Chen, Chun, Chen, Qibin, Ke
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The Median Effective Dose of Ketamine and Gabapentin in Opioid-Induced Hyperalgesia in Rats
Anesthesia & Analgesia, 2011Ketamine and gabapentin have been shown to prevent the delayed hyperalgesia induced by short-term use of systemic opioids. The mechanism of this action is believed to be likely at the spinal level, through an antagonism of the N-methyl-D-aspartate receptors for ketamine, and through a specific binding site for gabapentin.
Alain C, Van Elstraete +3 more
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Specifications for Calculating. The Median Effective Dose
American Industrial Hygiene Association Quarterly, 1953C S, WEIL, C P, CARPENTER, H F, SMYTH
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Carcinogenesis, 1980
Experimental dose-effect relationships of carcinogens following either acute (single dose) or chronic (time to tumor) exposure appears to conform with the median-effect principle (Chou, J. Theor. Biol. 59, 253-276, 1976) of the mass-action law: f(a)/ (1 - f(a)) = (D/D(m))m, where D is dose or cumulative dose, D(m) is the D required for the median ...
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Experimental dose-effect relationships of carcinogens following either acute (single dose) or chronic (time to tumor) exposure appears to conform with the median-effect principle (Chou, J. Theor. Biol. 59, 253-276, 1976) of the mass-action law: f(a)/ (1 - f(a)) = (D/D(m))m, where D is dose or cumulative dose, D(m) is the D required for the median ...
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Toxicology and Industrial Health, 1989
The development of the widely-used median effective (or lethal) dose as a summary measure in quantifying toxic response to chemical stimuli is reviewed. Attention is directed at those mathematical properties noted by the originator of the median effective dose, the English physiologist John William Trevan, that make the measure a useful summary ...
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The development of the widely-used median effective (or lethal) dose as a summary measure in quantifying toxic response to chemical stimuli is reviewed. Attention is directed at those mathematical properties noted by the originator of the median effective dose, the English physiologist John William Trevan, that make the measure a useful summary ...
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