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Median effective dose of isoflurane, sevoflurane, and desflurane in green iguanas
American Journal of Veterinary Research, 2006Abstract Objective—To determine the median effective dose (ED50; equivalent to the minimum alveolar concentration [MAC]) of isoflurane, sevoflurane, and desflurane for anesthesia in iguanas. Animals—6 healthy adult green iguanas. Procedure—In unmedicated iguanas, anesthesia was induced and maintained with each of the 3 volatile drugs administered on ...
Linda S, Barter +4 more
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Median effective dose of propofol required for induction of anesthesia in goats
Journal of the American Veterinary Medical Association, 1997Objective— To determine the median effective dose (ED 50 ) of propofol required for induction of anesthesia in goats and the frequency of myoclonic activity and apnea associated with propofol administration.
L S, Pablo, J E, Bailey, J C, Ko
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Interpretation of confidence intervals for median effective dose estimates
Environmental Toxicology and Chemistry, 1989Abstract Philosophical considerations in the interpretation of probability can confuse the meaning of interval estimates. Most techniques for calculating interval estimates for the median effective dose (LC50) have been developed under a Neyman-Pearson probability structure, which requires interpretation in terms of asymptotic ...
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Misuse of âDeduced Ratiosâ in the Estimation of Median Effective Doses
Nature, 1947Dragstedt and Lang1 wrote: “It seems to us obvious that a rabbit that died from 100 mgm. would have died of any higher dose and one that survived from 150 mgm. per kilogram would have survived from any lesser dose”, and tabulated their “mortality percentages” as deduced according to “this rationale” from experienced ratios at the various doses ...
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Anesthesiology, 2005
Background The study was designed to determine and compare the median effective doses (MEDs) of intrathecal ropivacaine with levobupivacaine for labor analgesia. Methods In this double-blind study, 100 parturients in early labor were randomized to receive either intrathecal ...
Alex T, Sia +3 more
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Background The study was designed to determine and compare the median effective doses (MEDs) of intrathecal ropivacaine with levobupivacaine for labor analgesia. Methods In this double-blind study, 100 parturients in early labor were randomized to receive either intrathecal ...
Alex T, Sia +3 more
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Optimal Bayesian estimation of the median effective dose
Journal of Statistical Planning and Inference, 1988This paper provides some properties of the Fisher information function arising in quantal response bioassay, attribute life testing and dilution assay models. It is shown that the Fisher information function (arising in probit, logit and extreme value models) is a totally positive function of order 2 and consequently unimodal as a function of the ...
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A STUDY OF THE INDIVIDUAL MEDIAN EFFECTIVE DOSE OF OESTRONE IN THE OVARIECTOMIZED MOUSE
Journal of Endocrinology, 1955SUMMARY Two methods of estimating the individual median effective dose have been studied and found to yield equivalent estimates. Within-animal variation (over a period of 5 weeks) is shown to be 29% (20–38%) of the between-animal variation.
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Anesthesia & Analgesia, 2005
Tramadol is a centrally-acting analgesic drug. In a search of an effective balanced analgesia technique with a morphine-sparing component, we studied the median effective analgesic doses (ED(50)) of tramadol, morphine, and their combination to determine the nature of their interaction using an isobolographic analysis.
Thi Aurore, Marcou +3 more
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Tramadol is a centrally-acting analgesic drug. In a search of an effective balanced analgesia technique with a morphine-sparing component, we studied the median effective analgesic doses (ED(50)) of tramadol, morphine, and their combination to determine the nature of their interaction using an isobolographic analysis.
Thi Aurore, Marcou +3 more
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Optimal Bayesian sequential estimation of the median effective dose
Biometrika, 1970This paper concerns the sequential design of experiments for estimating the median lethal dose parameter of a quantal, logistic dose response curve. Bayesian decision theory is used to provide a stopping rule and terminal decision rule to minimize the prior expectation of the total cost of observation plus estimation loss. Special cases in which trials
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VARIOUS METHODS OF INTERVAL ESTIMATION OF THE MEDIAN EFFECTIVE DOSE
Communications in Statistics - Simulation and Computation, 2001The bootstrap, a resampling approach to statistical inference, has been recommended as an alternative to the more traditional parametric approaches. Assuming a logistic dose-response curve, a number of studies have investigated the percentage coverage probabilities of various methods of interval estimation of the median effective dose (ED50).
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