Estimation of the Median Lethal Dose When Responses within a Litter are Correlated
Biometrics, 1981In the analysis of mortality experiments on neonatal animals, the presence of litter effects may prevent the use of probit analysis. This communication presents a method for estimating the median lethal dose, based on a modification of the beta-binomial distribution.
A C, Segreti, A E, Munson
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Efficient Design for Estimation of Median Lethal Dose and Quantal Dose- Response Curves
Biometrics, 1990The results of quantal dose-response experiments are often summarized by an estimate of the "median lethal dose," denoted LD50, and many sequential designs have been proposed for efficient estimation of LD50. These designs strive to produce a sequence of trials at dose levels that get closer and closer to LD50.
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[Comparison of the decurarizing and median lethal doses of 2-aminopyridine salts].
Eksperimentalna meditsina i morfologiia, 1979The authors determined LD50 of 2-aminopyridine hydrochloride, 2-aminopyridine jodmethylate, 2-aminopyridine methyl-para-toluolsulfonat and pymadine (4-aminopyridine hydrochloride) in mice and rats after subcutaneous administration. They found that doses of the same compounds during indirect stimulation of m.
V, Spasov, D, Getova, A, Spasov
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Measurement of median lethal dose as a rapid indication of contaminant toxicity to fish
Environmental Toxicology and Chemistry, 1984Abstract A new method was developed to rapidly measure the toxicity of contaminants to fish over 96 h. The method is the measurement of median lethal doses by intraperitoneal injection (IP-LD50). Contaminants are dissolved in 5% ethanol in saline or in cod-liver oil and injected at a rate of 1.0 ml per 100 g of fish.
P. V. Hodson +2 more
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Determination of the Median Lethal Dose of Botulinum Serotype E in Channel Catfish Fingerlings
Journal of Aquatic Animal Health, 2012Abstract The median lethal dose of botulinum serotype E in 5.3-g channel catfish Ictalurus punctatus fingerlings was determined. Five tanks (five fish/tank) were assigned to each of the following treatment groups: 70, 50, 35, 25, or 15 pg of purified botulinum serotype E.
Kamalakar, Chatla +4 more
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The application of Poisson units to the determination of median lethal cell culture dose
Toxicology in Vitro, 2001The median lethal cell culture dose (CCLD(50)) and its 95% confidence interval were determined using the Behrens and Kärber area method with subsequent regression analysis by the action of methylmercury iodide (CH(3)HgI; MMI) on monolayer cultures of HeLa cells. The concentrations of MMI were 0.45, 0.9, 1.8, 3.65, 7.3 and 14.6 microM/l. The duration of
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Median lethal dose (LD50) evaluation of some polyherbal formulations marketed in northern Nigeria
International Journal of Herbs and Pharmacological Research, 2015The polyherbal preparations reported here are traditionally used in Northern Nigeria for the treatment of wide range of illnesses. The aim of this study was to evaluate the acute toxicity potential of 70% ethanol extracts of forty polyherbal products by determining their median lethal dose (LD50) estimates intraperitoneally and orally using the Lorke’s
Aliyu, M +3 more
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Retraction: Statistical model for estimating the median lethal dose of breast cancer
AIP Conference Proceedings, 2023Shaima Abbas Jasim +2 more
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