Results 61 to 70 of about 112,587 (303)

STUDY OF ACUTE TOXICITY OF DIFFERENT PREPARATION OF OLEANDER LEAVES IN MICE [PDF]

Basrah Journal of Veterinary Research, 2008
Three preparations of dried oleander leaves were prepared. The first one was by extraction with hexane; the second by extraction with 70% ethanol while the third was suspended as a whole ground leaves in distilled water.
Lubna A. Kafi, Rana A. Sailh, Ali A. Al-Khayyat   +2 more
doaj   +1 more source

The dose makes the poison: have “field realistic” rates of exposure of bees to neonicotinoid insecticides been overestimated in laboratory studies? [PDF]

, 2014
Recent laboratory based studies have demonstrated adverse sub-lethal effects of neonicotinoid insecticides on honey bees and bumble bees, and these studies have been influential in leading to a European Union moratorium on the use of three neonicotinoids,
BARON G L, BONMATIN J M, BONMATIN J M, CARRECK N L, EUROPEAN COMMISSION, EUROPEAN FOOD SAFETY AUTHORITY, EUROPEAN FOOD SAFETY AUTHORITY, EUROPEAN FOOD SAFETY AUTHORITY, FELTHAM H, Francis L W Ratnieks, GARBUZOV M, MAUS C, Norman L Carreck, OSBORNE J L, SCHMUCK R, SCHÖNING R, THOMPSON H   +16 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Determination of lethal and mutation induction doses of gamma rays for gladiolus (Gladiolus grandifloras Hort.) genotypes

Heliyon
Gladiolus is a highly allogamous flower plant, but owing to the prolonged juvenile phase, asexual propagation is preferred, which acts as a barrier for the induction of natural genetic variability in gladiolus. Therefore, the induced mutagenesis could be
Anand Singh Rawat, B.D. Bhuj, Ranjan Srivastava, Satish Chand, N.K. Singh, Yashpal Singh Bisht, Hemant Dasila, Rajendra Bhatt, Kahkashan Perveen, Najat A. Bukhari   +9 more
doaj   +1 more source

Estimations of the lethal and exposure doses for representative methanol symptoms in humans

Annals of Occupational and Environmental Medicine, 2017
Background The aim of this review was to estimate the lethal and exposure doses of a representative symptom (blindness) of methanol exposure in humans by reviewing data from previous articles.
Chan-Seok Moon
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Female rats are less susceptible during puberty to the lethal effects of percutaneous exposure to VX

Toxicology Reports, 2016
Nerve agents with low volatility such as VX are primarily absorbed through the skin when released during combat or a terrorist attack. The barrier function of the stratum corneum may be compromised during certain stages of development, allowing VX to ...
Linnzi K.M. Wright, Robyn B. Lee, Edward D. Clarkson, Lucille A. Lumley   +3 more
doaj   +1 more source

The Impact of Age and Sex on Mouse Models of Melioidosis

Pathogens, 2020
Mouse models have been used to generate critical data for many infectious diseases. In the case of Burkholderia pseudomallei, mouse models have been invaluable for bacterial pathogenesis studies as well as for testing novel medical countermeasures ...
Christopher P. Klimko, Sylvia R. Treviño, Alicia M. Moreau, Michael J. Aponte Cuadrado, Joshua R. Meyer, David P. Fetterer, Susan L. Welkos, Patricia L. Worsham, Norman Kreiselmeier, Carl Soffler, Christopher K. Cote   +10 more
doaj   +1 more source

Factors modifying the response of large animals to low-intensity radiation exposure [PDF]

, 1972
In assessing the biological response to space radiation, two of the most important modifying factors are dose protraction and dose distribution to the body.
Page, N. P., Still, E. T.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source