Results 71 to 80 of about 112,587 (303)

Evaluation of the Anti-Plasmodial potential of Calotropis procera Latex in mice infected with Plasmodium berghei

MethodsX, 2021
Current artemisinin-based combination therapy (ACT) regimen for the treatment of malaria is effective, but cases of malaria parasite's resistance to existing antimalarial drugs is worrisome.
Johnson Adejoh, Lukman A. Alli, Michael P. Okoh   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Insecticidal Activity of Plectranthus amboinicus Essential Oil against the Stable Fly Stomoxys calcitrans (Diptera: Muscidae) and the Horse Fly Tabanus megalops (Diptera: Tabanidae)

Insects, 2022
The stable fly, Stomoxys calcitrans (Diptera: Muscidae), and the horse fly, Tabanus megalops (Diptera: Tabanidae), are important ectoparasites of livestock in Thailand. These species affect animal health and cause economic losses. This study investigated
Arpron Leesombun, Sivapong Sungpradit, Sookruetai Boonmasawai, Thekhawet Weluwanarak, Suriyo Klinsrithong, Jiraporn Ruangsittichai, Sumate Ampawong, Roungthip Masmeatathip, Tanasak Changbunjong   +8 more
doaj   +1 more source

Solar X-ray Flare Hazards on the Surface of Mars [PDF]

, 2006
Putative organisms on the Martian surface would be exposed to potentially high doses of ionizing radiation during strong solar X-ray flares. We extrapolate the observed flare frequency-energy release scaling relation to releases much larger than seen so ...
Aschwanden, Aschwanden, Audard, Baker, Battaglia, Battista, Becker, Boynton, Bromund, Christian, Cockell, Cordoba-Jabonero, Cravens, Crosby, David S. Smith, De Angelis, Dennerl, Dion, DiRuggiero, Dubrova, Farkas, Favata, Ferreira, Fielden, Forster, Friedberg, Gunell, Güdel, Haisch, Hawley, Hudson, John Scalo, Kanbach, Kopylov, Krucker, Lee, Liebert, Lin, Mancinelli, Mileikowsky, Molina-Cuberos, Pagano, Pavlov, Qiu, Randall, Reedy, Rohwer, Rubenstein, Russell, Ryan, Saganti, Sankaranarayanan, Sankaranarayanan, Schaefer, Schimmerling, Schuerger, Setlow, Smith, Smith, Sparrow, Sparrow, Stothers, Sutherland, Turner, Veronig, Violot, von Sonntag, Ward, Wilson, Woods, Wänke   +70 more
core   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Calculation of 95% confidence interval of the median lethal dose determined by the up-and-down procedure: a letter to editor

Journal of Ideas in Health, 2022
Acute toxicity of chemicals can be determined by the up-and-down procedure (UDP) to measure the median lethal dose (LD50) in laboratory animals.
Fouad Kasim Mohammad
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. [PDF]

, 2017
We developed a systematic approach to map human genetic networks by combinatorial CRISPR-Cas9 perturbations coupled to robust analysis of growth kinetics.
A Baryshnikova, A Baryshnikova, A DeLean, Aaron N Chang, AE Briner, Alex N Beckett, Alex Thomas, AM Kabadi, Amanda Birmingham, Ana Bojorquez-Gomez, ASL Wong, Assen Roguev, B Vogelstein, C Laufer, Chih-Chung Kuo, CJ Lord, Dan Du, Daniel Pekin, Dongxin Zhao, F Lori, H Xu, J Shi, Jason F Kreisberg, JD Storey, Jens Luebeck, JG Doench, John Paul Shen, Katherine Licon, Kristin Klepper, KS Pollard, Kyle Salinas Sanchez, L Avery, LA Gilbert, Lei Qi, M Costanzo, M Martin, MC Bassik, MS Neshat, Nathan E Lewis, NE Sanjana, Nevan Krogan, NJ Krogan, P Mali, P Mali, Prashant Mali, R Chari, R Mani, R Srivas, Roman Sasik, S Bandyopadhyay, SR Collins, T Hart, T Horn, Trey Ideker, VG Tusher, Y Benjamini, Y Dang   +56 more
core   +1 more source

median lethal dose

, 2014
Citation: 'median lethal dose' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.M03810 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

The Robbins–Monro Method for Estimating the Median Lethal Dose

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1965
Summary The Robbins–Monro method provides a sequential plan that gives an attractively simple estimate of the LD50 in bioassay and is practicable for agents in which the response (death or survival) is known within an hour. By machine computations, its performance is examined for experiments using 50 or less animals.
W. G. Cochran, M. Davis
openaire   +1 more source