Results 91 to 100 of about 711,203 (301)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The mediating effect of gaming motivation between psychiatric symptoms and problematic online gaming: an online survey [PDF]

, 2015
Background: The rapid expansion of online video gaming as a leisure time activity has led to the appearance of problematic online gaming (POG). According to the literature, POG is associated with different psychiatric symptoms (eg, depression, anxiety ...
Demetrovics, Z, Griffiths, MD, Király, O, Kökönyei, G, Nagygyörgy, K, Urbán, R, Ágoston, C   +6 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

CACNA1C Gene rs11832738 Polymorphism Influences Depression Severity by Modulating Spontaneous Activity in the Right Middle Frontal Gyrus in Patients With Major Depressive Disorder

Frontiers in Psychiatry, 2020
ObjectivesThis study aimed to examine whether the CACNA1C gene rs11832738 polymorphism and major depressive disorder (MDD) have an interactive effect on the untreated regional amplitude of low-frequency fluctuation (ALFF) and to determine whether ...
Xiaoyun Liu, Zhenghua Hou, Yingying Yin, Chunming Xie, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Yonggui Yuan   +7 more
doaj   +1 more source

Obesity, perceived weight discrimination, and psychological well-being in older adults in England [PDF]

, 2015
Objective To examine whether the adverse effect of obesity on psychological well-being can be explained by weight discrimination. Methods The study sample included 5056 older (≥50 y) men and women living in England and participating in the English ...
Beeken, RJ, Jackson, SE, Wardle, J
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Mediation Effect of Trust on the Relationship Between Perception of Organization Politics and Commitment [PDF]

, 2009
This paper is the extension study of the relationship between perception of organiza-tion politics (POP), and commitment. This study investigates how trust explained therelation between these relationships.
Indartono, S. (Setyabudi)
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Interacting and joint effects of triglyceride-glucose index and body mass index on future endometrial cancer risk and the mediating role of body mass index: a cross-sectional study

Frontiers in Endocrinology
BackgroundThe triglyceride-glucose (TyG) index, a promising biomarker for insulin resistance, is linked to the risk of various metabolic-related cancers.
Yixiao Wang, Yixiao Wang, Wenzhi Kong, Wenzhi Kong, Yuning Geng, Yuning Geng, Chunyu Xu, Chunyu Xu, Jinwei Miao, Jinwei Miao   +9 more
doaj   +1 more source