Results 101 to 110 of about 711,203 (301)

Pengaruh Likuiditas, Financial Leverage, Aktivitas terhadap Return Saham dengan Profitabilitas sebagai Variabel Mediasi [PDF]

, 2016
This research aims to analyze direct and indirect effect about liquidity, financial leverage and activities on stock return and with the mediation of ROA as a proxy of profitability ratio.
Ghasarma, R. (Reza), Kurniawan, T. (Teddy), Yuliani, Y. (Yuliani)   +2 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Moderating and Mediating Effects of Over-Commitment on the Association Between Effort–Reward Imbalance (ERI) with Upper Back and Hand/Wrist Disorders in Municipal Solid Waste Collectors

Journal of Pain Research, 2022
Wen-Yu Lin,1,2 Ching-Lan Yang,3 Wei-Ping Huang,1 Po-Chang Tseng,1,4 Hsien-Wen Kuo1,5 1Institute of Environmental and Occupational Health Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; 2Taiwan’s Environmental Protection Agency, Taipei,
Lin WY, Yang CL, Huang WP, Tseng PC, Kuo HW   +4 more
doaj  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The impact of college students’ parent–child attachment on bullying behavior: the mediating role of external expression of anger

Frontiers in Psychology
Purpose(1) To investigate the relationship between college students’ parent–child attachment, external expression of anger, and bullying behavior; (2) To explore the mediating role of external expression of anger between parent–child attachment and ...
Ruixin Wang, Yiwen Chen, Zhenyu Zhao, Mengmeng Zhao, Ziying Wang, Hongge Luo, Lina Li   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Do psychobiosocial states mediate the relationship between perceived motivational climate and individual motivation in youngsters? [PDF]

Grounded in achievement goal theory and self-determination theory, this cross-sectional study examined the relationship between perceived motivational climate and individuals’ motivation as well as the mediation effect of psychobiosocial states as ...
Bertollo, Maurizio, Bortoli, Laura, Filho, Edson, Robazza, Claudio   +3 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

On Partial Identification of the Pure Direct Effect [PDF]

, 2015
In causal mediation analysis, nonparametric identification of the pure (natural) direct effect typically relies on, in addition to no unobserved pre-exposure confounding, fundamental assumptions of (i) so-called "cross-world-counterfactuals" independence
Kanki, Phyllis, Meloni, Seema, Miles, Caleb H., Tchetgen, Eric J. Tchetgen   +3 more
core   +3 more sources