Results 141 to 150 of about 4,232,046 (375)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Regional Medical Campuses in Canada

open access: yesJournal of Regional Medical Campuses
Background: Regional Medical Campuses (RMCs) are an established part of the Distributed Medical Education (DME) landscape in Canada. Combined model RMCs, offering both preclinical and clinical education have shown promising results in producing ...
Aaron Johnston   +4 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Docência no ensino médico: por que é tão difícil mudar?

open access: yesRevista Brasileira de Educação Médica
Apesar do reconhecimento da necessidade de mudanças no ensino médico, a prática docente tem-se mostrado resistente a modificações. Este trabalho de revisão identifica os fatores que limitam mudanças na prática docente em Medicina.
Nilce Maria da Silva Campos Costa
doaj   +1 more source

Enhancing Medical Anatomy Education through Virtual Reality (VR): Design, Development, and Evaluation [PDF]

open access: yesarXiv
Modern medicine demands innovations in medical education, particularly in the learning of human anatomy, traditionally taught through textbooks, dissections, and lectures. Virtual Reality (VR) has emerged as a promising tool to address the limitations of these conventional methods by emphasising vision-based and active learning.
arxiv  

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