Results 121 to 130 of about 9,201,948 (316)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Application of different radiation health risk metrics in medical exposure

open access: yesРадиационная гигиена
In recent years, several methodological documents have been approved and a number of scientific articles have been published concerning the assessment of radiation risks associated with medical exposure.
L. V. Repin   +3 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

open access: yesFEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés   +2 more
wiley   +1 more source

Medical Center grounds diagram

open access: yes
This glass lantern slide features a black and white diagram of the Medical College of South Carolina Medical Center ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core  

Medical College Hospital, 1953

open access: yes, 1953
This glass lantern slide features an aerial view of a color photograph of construction of the Medical College of South Carolina Hospital in mid ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core  

Correction: Park et al. ABCA1-Mediated EMT Promotes Papillary Thyroid Cancer Malignancy through the ERK/Fra-1/ZEB1 Pathway. Cells 2023, 12, 274

open access: yesCells
Error in Figure [...]
Ji-Hye Park   +11 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Medicolegal aspects of medical radiation exposure

open access: yesThe British Journal of Radiology, 1990
It is well known that untoward events may follow the exposure of human beings to ionizing radiations. As some such events may ensue after medical (in addition to other) exposures, it is appropriate to consider possible resultant legal complications of medical radiation exposures.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Medical College Hospital, May 1953

open access: yes, 1953
This glass lantern slide features an aerial view of the Medical College of South Carolina Hospital under construction in May ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core  

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