Results 41 to 50 of about 73,843 (199)

Inpatient palliative chemotherapy is associated with high mortality and aggressive end-of-life care in patients with advanced solid tumors and poor performance status

BMC Palliative Care, 2019
Background The benefit of palliative chemotherapy (PC) in patients with advanced solid tumors and poor performance status (ECOG-PS) has not been prospectively validated, which makes treatment decision challenging.
Vitor Fiorin de Vasconcellos, Renata RCC Bonadio, Guilherme Avanço, Marcelo Vailati Negrão, Rachel Pimenta Riechelmann   +4 more
doaj   +1 more source

Futility Analysis in the Cross-Validation of Machine Learning Models [PDF]

, 2014
Many machine learning models have important structural tuning parameters that cannot be directly estimated from the data. The common tactic for setting these parameters is to use resampling methods, such as cross--validation or the bootstrap, to evaluate
Kuhn, Max
core  

Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCT

Efficacy and Mechanism Evaluation, 2020
Background: Microvascular obstruction commonly affects patients with acute ST-segment elevation myocardial infarction and is independently associated with adverse outcomes.
Peter J McCartney, Hany Eteiba, Annette M Maznyczka, Margaret McEntegart, John P Greenwood, Douglas F Muir, Saqib Chowdhary, Anthony H Gershlick, Clare Appleby, James M Cotton, Andrew Wragg, Nick Curzen, Keith G Oldroyd, Mitchell Lindsay, J Paul Rocchiccioli, Aadil Shaukat, Richard Good, Stuart Watkins, Keith Robertson, Christopher Malkin, Lynn Martin, Lynsey Gillespie, Thomas J Ford, Mark C Petrie, Peter W Macfarlane, R Campbell Tait, Paul Welsh, Naveed Sattar, Robin A Weir, Keith A Fox, Ian Ford, Alex McConnachie, Colin Berry   +32 more
doaj   +1 more source

Ventilação mecânica e obstinação terapêutica ou distanásia, a dialéctica da alta tecnologia em medicina intensiva

Revista Portuguesa de Pneumologia, 2006
Resumo: Distanásia ou qualquer um dos seus sinónimos é uma consequência do excesso terapêutico em relação ao prognóstico esperado. A obstinação terapêutica é um dos dilemas éticos mais angustiantes no quotidiano de medicina intensiva, apesar de a sua ...
Filipe Monteiro
doaj   +1 more source

Bayesian clinical trial designs : Another option for trauma trials? [PDF]

, 2017
The UK-REBOA Trial is funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme (project number 14/199/09). PP was supported by the MRC Network of Hubs for Trials Methodology Research (MR/L004933/1-R/N/P/B1).
Campbell, Marion K., Jansen, Jan O., MacLennan, Graeme, Pallmann, Philip, UK-REBOA Trial Investigators   +4 more
core   +2 more sources

Outcomes of Cardiopulmonary Resuscitation and Estimation of Healthcare Costs in Potential ‘Do Not Resuscitate’ Cases

Sultan Qaboos University Medical Journal, 2016
Objectives: Cardiopulmonary resuscitation (CPR) is a life-saving procedure which may fail if applied unselectively. ‘Do not resuscitate’ (DNR) policies can help avoid futile life-saving attempts among terminally-ill patients.
Akhwand S. Ahmad, Sayed Mudasser, Muhammad N. Khan, Hafiz N. H. Abdoun   +3 more
doaj   +1 more source

Advantages of Bayesian monitoring methods in deciding whether and when to stop a clinical trial: an example of a neonatal cooling trial. [PDF]

, 2016
BackgroundDecisions to stop randomized trials are often based on traditional P value thresholds and are often unconvincing to clinicians. To familiarize clinical investigators with the application and advantages of Bayesian monitoring methods, we ...
Bell, Edward F, Das, Abhik, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Laptook, Abbot, Pedroza, Claudia, Shankaran, Seetha, Tyson, Jon E   +6 more
core  

Renouncement of renal replacement therapy: withdrawal and refusal

Brazilian Journal of Nephrology
Renouncement of renal replacement therapy (RRT) is a medical dilemma. This review covers the concept, the magnitude, the prognosis, and discusses strategies and management approaches about this subject in patients with CKD and AKI. Evidence suggests that
José Andrade Moura Neto, Ana Flávia de Souza Moura, José Hermógenes Rocco Suassuna   +2 more
doaj   +1 more source

The persistent vegetative state: legal and ethical issues [PDF]

, 1995
Recent advances in technology and medical expertise have enabled doctors to prolong the lives of many severely injured patients who only a few years ago would have died from their injuries. The prolongation of life by such measures has raised many legal,
Dobson, Rosemary
core  

A phase II multicentre, open-label, proof-of-concept study of tasquinimod in hepatocellular, ovarian, renal cell, and gastric cancers [PDF]

, 2017
Background: Tasquinimod is a small molecule with immunomodulatory, anti-angiogenic, and anti-metastatic properties that targets the tumor microenvironment.
Bjarnason, Georg A, Edeline, Julien, Escudier, Bernard, Faivre, Sandrine, Fartoux, Laetitia, Germann, Nathalie, Hirte, Hal, Jones, Robert, Mackay, Helen, Oza, Amit, Plummer, Ruth, Pouget, Jean-Christophe, Thistlethwaite, Fiona, Van Cutsem, Eric, Vergote, Ignace   +14 more
core   +1 more source