Results 121 to 130 of about 5,138,843 (349)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

On the History of Creation of the Atlas of Tibetan Medicine (17th century): source aspects

open access: yesМонголоведение
Introduction. The article examines the history of the creation of the set of illustrations the Atlas of Tibetan Medicine (also known as Tibetan Medical Paintings) by Desi Sangye Gyatso (1653–1705) to his Vaiḍūrya sngon po, which is a drudrel (‘bru ‘grel)
Yumzhana Zh. Zhabon
doaj   +1 more source

Cinchona amazonica Standl. (Rubiaceae) in the state of Acre, Brazil [PDF]

open access: yesBoletim do Museu Paraense Emílio Goeldi. Ciências Naturais, 2006
The present research is about dendrology, geographic distribution and status of conservation of Cinchona amazonica Standl. with are plants with medical interest; they grow in the state of Acre, Brazil.
Percy Amilcar Zevallos Pollito   +1 more
doaj  

Comparison of two 3D scanning software to identify facial features: a prospective instrument to predict difficult airway

open access: yesPerioperative Medicine
Background Clinical airway assessment has limited predictive ability to anticipate difficult airway. Three-dimensional (3D) technologies have emerged in medicine as valuable tools in different settings including innovation and surgical planning.
Alexander Rocuts   +6 more
doaj   +1 more source

Breaking boundaries in neurosurgery through art and technology: A historical perspective

open access: yesBrain and Spine
Introduction: Since the past, art has been used as a tool to elaborate anatomical knowledge and guide surgeons to perform surgeries. Through the eras, art has taken role by conveying the knowledge to people in forms of illustrations and models, including
Nadya Zaragita   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Research on Test Method of Active Medical Device Preset Service Life Evaluation

open access: yesZhongguo yiliao qixie zazhi
When applying for registration of an active medical device, it is necessary to submit research and verification data regarding the device's service life.
Fei HE, Weiming WANG
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Integrating Serious Games into the Medical Curriculum: Recognizing Challenges and Exploring Remedies

open access: yesJournal of Pharmacy and Bioallied Sciences
Medical education is complex in nature, acknowledging the fact that the knowledge base is extremely vast and dynamic, and the number of skills that students must acquire during their period of training is also huge.
Saurabh RamBihariLal Shrivastava   +2 more
doaj   +1 more source

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