Results 81 to 90 of about 2,823,528 (278)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Diagnostic approach to Haematologic Malignancies in Resource-Limited Settings- A Review

Sokoto Journal of Medical Laboratory Science
Haematologic malignancies encompass a diverse group of cancers originating in the blood, bone marrow, and lymphatic system. Such diseases pose a significant health burden in Africa.
Elujoba O. Samson1,2*, Ibrahim Adamu1,3. Igbe Mba1,4, Adepoju Emmanuel1,5, Babajimi-Joseph Amarachi1,6, Muhibi Musa1 Department of Medical Laboratory Sciences
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Geographical access to medical laboratory services in Shiraz, Hamadan and Shushtar: a GIS-based study

Payesh, 2017
Objective (s): Equity in distribution of health services is one of the goals of health policy makers. Thus, an study entitled “modeling geographical access to medical laboratory services in Iran” was conducted in 2014. The present article is a case study
Jila Sadighi, Ali Hosseini, Kazem Mohammad, Saeed Mahdavi, Siamak Mirab Samiee, Nooshafarin Safadel, Vahid Banaei, Rahele Rostami, Leila Haydari, Fatemeh Gorjikhah, Maryam Mansoori   +10 more
doaj  

The Caduceus & Medical Laboratory Professionals - The Significance of Professional Identity! [PDF]

, 2023
Angela Tomei Robinson
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Medical Laboratory Haematology [PDF]

Journal of Clinical Pathology, 1985
  +4 more sources

Prevalence and postural risk factors associated with musculoskeletal disorders among medical laboratory personnel in Kashan 2012

Salāmat-i kār-i Īrān, 2016
Background and aims: Musculoskeletal disorders are the most prevalent occupational injuries and disability in the world. One of the most important risk factors of these disorders is awkward posture.
S Falaki, H Akbari, M Derakhshan, M Hannani, M Motalebi Kashani   +4 more
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Geographical accessibility to medical laboratory services in Iran: Takab case study

Payesh, 2015
Objective (s): One of the most important strategies to achieve equity is facilitating population access to health services. As such geographical accessibility modeling was suggested.
Jila Sadighi, Ali Hosseini, Kazem Mohammad, Saeed Mahdav, Siamak Mirab Samiee, Nooshafarin Safade, Vahid Banaei, Katayoun Jahangiri, Rahele Rostam, Ziba EslamiNejad   +9 more
doaj