Results 111 to 120 of about 319,416 (265)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Exploring UK medical schools' perception and intent for teaching on antimicrobial resistance and stewardship. [PDF]

JAC Antimicrob Resist
Lambert ZL, Weeks S, Dissanayake O, Boyd SE, Mughal N, Moore LSP, Pallett SJC.   +6 more
europepmc   +2 more sources

Teaching Empathy? Implementing Theatre Pedagogy in the Medical School Curriculum

Critical Stages, 2018
The US Medical Licensing Examination requires future doctors to examine actors in simulated, improvisational scenarios to test students’ ability to empathetically collect medical histories, perform basic examinations and diagnose an illness.
Elisabeth Hostetter, Melanie Stewart
doaj  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Mayo Medical School

Academic Medicine, 2010
Barbara L, Porter, Joseph P, Grande
openaire   +3 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

878 T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants

Journal for ImmunoTherapy of Cancer, 2023
David Ng, Katherine S Panageas, Jedd D Wolchok, Taha Merghoub, Sadna Budhu, Olivier De Henau, Yanyun Li, Billel Gasmi, Cailian Liu, Sara Schad, Rebekka Duhen, Andrew D Weinberg, Mathieu Gigoux, David Redmond, David Schroder, Andrew Chow, Daniel Hirschhorn, Lukas kraehenbuehl, Isabell Schulze, Aliya Holland, Jean Albrengues, Mikala Egeblad, Arshi Arora, Xue-Yan He, Linda Hamadene, Travis Hollmann, Jacob M Ricca, Levi Mark B Mangarin, Anne-Laure Flamar, Heyjin Choi, Czrina A Cortez, Allison Betof Warner, Gabrielle A Rizzuto, Christine N Spencer   +33 more
doaj   +1 more source

The Financing of Medical Schools [PDF]

Science, 1954
openaire   +2 more sources

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source