Results 41 to 50 of about 1,460,105 (366)

Research knowledge and skills in primary medical training: A crosssectional audit [PDF]

open access: yes, 2016
This article was migrated. The article was marked as recommended. Background: Internationally, medical education has either adopted, or is moving toward, a Masters level qualification at completion.
Allen, Penny   +3 more
core   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

CCT4 promotes tunneling nanotube formation

open access: yesFEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto   +3 more
wiley   +1 more source

Standardized patient program: Student feedback

open access: yesAsian Journal of Medical Sciences, 2016
Objective: Standardized patients (SPs) are widely used in medical and other health professions education. At xxxx SPs have been used for teaching-learning and assessment of basic science medical students since January 2013. The opinion of SPs about their
PR Shankar
doaj   +1 more source

Diet-induced prediabetes: effects of exercise treatment on risk factors for cardiovascular complications

open access: yesNutrition & Metabolism, 2021
Background An animal model of prediabetes that has been developed in our laboratory using a high fat high carbohydrate diet and lack of physical activity displays risk factors for cardiovascular complications.
Mluleki Luvuno   +2 more
doaj   +1 more source

Systematic review of pain medicine content, teaching, and assessment in medical school curricula internationally [PDF]

open access: yes, 2018
Introduction: Pain management is a major health care challenge in terms of the significant prevalence of pain and the negative consequences of poor management.
Bate, Frank   +5 more
core   +3 more sources

A medical school in Zambia [PDF]

open access: yesJournal of Public Health, 1997
The Medical School in Zambia was founded in 1968, some four years after independence. The first graduates qualified in 1973, and over the intervening 23 years there have been some 700 medical graduates, 600 of them Zambian.These doctors are now working all over the world, and the standard of their training compares favourably with that at medical ...
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

An azoospermic male with a novel chromosome 46, XX, der(15)t(Y; 15)(p11.3; p12)

open access: yesClinical Case Reports, 2022
Male individuals with a 46, XX karyotype are commonly diagnosed with 46, XX male sex reversal syndrome, one of the rarest sex chromosomal anomalies. In this case, we report a rare XX male with Y‐specific DNA sequences located near the end of chromosome ...
Jiebin Wu   +4 more
doaj   +1 more source

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