Results 1 to 10 of about 1,923,096 (295)
Frontiers in Pharmacology, 2021 Recent research indicates that brain cannabinoid CB2 receptors are involved in drug reward and addiction. However, it is unclear whether β-caryophyllene (BCP), a natural product with a CB2 receptor agonist profile, has therapeutic effects on ...
Xiang-Hu He +8 more
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Use of Nanocarriers Containing Antitrypanosomal Drugs for the Treatment of Chagas Disease
Pharmaceuticals, 2023 Chagas disease, caused by the Trypanosoma cruzi parasitic protozoan, is a neglected tropical disease (NTD) of significant incidence in Latin America.
Diogo de Freitas Paiva +6 more
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Pharmacology Research & Perspectives, 2023 Low‐efficacy mu‐opioid receptor (MOR) agonists represent promising therapeutics, but existing compounds (e.g., buprenorphine, nalbuphine) span a limited range of low MOR efficacies and have poor MOR selectivity.
Edna J. Santos +11 more
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Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor
Biomolecules, 2021 The dopamine D2/D3 receptor (D2R/D3R) agonists are used as therapeutics for Parkinson’s disease (PD) and other motor disorders. Selective targeting of D3R over D2R is attractive because of D3R’s restricted tissue distribution with potentially fewer side ...
Pramisha Adhikari +7 more
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Stakeholder perceptions of lethal means safety counseling: A qualitative systematic review
Frontiers in Psychiatry, 2022 IntroductionLethal means safety counseling (LMSC) is an evidence-based suicide prevention intervention during which providers encourage patients to limit their access to lethal means (e.g., firearms, medications).
Gabriela Kattan Khazanov +11 more
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Acute Heart Failure Is a Malignant Process: But We Can Induce Remission
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Acute heart failure is a common and increasingly prevalent condition, affecting >10 million people annually. For those patients who survive to discharge, early readmissions and death rates are >30% everywhere on the planet, making it a malignant ...
Gad Cotter +6 more
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Annals of Biomedical Engineering, 2018 Medical robotics encompasses surgical, therapeutic and rehabilitative devices that are changing medicine and healthcare. Although the field of medical robotics predates Intuitive’s da Vinci by more than a decade, it was the clinical and commercial achievements of that system that brought medical robotics to widespread patient and public attention.
Elson, DS +4 more
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Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats
Cell Reports, 2017 Cocaine users show reduced expression of the metabotropic glutamate receptor (mGluR2), but it is not clear whether this is a predisposing trait for addiction or a consequence of drug exposure.
Hong-Ju Yang +5 more
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Analysis of potential risk factors associated with COVID-19 and hospitalization
Frontiers in Public Health, 2022 Coronavirus disease 2019 (COVID-19) was found to cause complications in certain groups of people, leading to hospitalization. Several factors have been linked to this, such as gender, age, comorbidity, and race.
Abdul-Hakeem Moazi Alharbi +21 more
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Pharmaceutics, 2023 Modified polymeric gels, including nanogels, which play not only the role of a bioinert matrix, but also perform regulatory, catalytic, and transport functions due to the active fragments introduced into them, can significantly advance the solution to ...
Veronika Smagina +3 more
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