Results 1 to 10 of about 1,693,150 (290)

β-caryophyllene, an FDA-Approved Food Additive, Inhibits Methamphetamine-Taking and Methamphetamine-Seeking Behaviors Possibly via CB2 and Non-CB2 Receptor Mechanisms

Frontiers in Pharmacology, 2021
Recent research indicates that brain cannabinoid CB2 receptors are involved in drug reward and addiction. However, it is unclear whether β-caryophyllene (BCP), a natural product with a CB2 receptor agonist profile, has therapeutic effects on ...
Xiang-Hu He, Xiang-Hu He, Ewa Galaj, Guo-Hua Bi, Yi He, Briana Hempel, Yan-Lin Wang, Eliot L. Gardner, Zheng-Xiong Xi   +8 more
doaj   +1 more source

Use of Nanocarriers Containing Antitrypanosomal Drugs for the Treatment of Chagas Disease

Pharmaceuticals, 2023
Chagas disease, caused by the Trypanosoma cruzi parasitic protozoan, is a neglected tropical disease (NTD) of significant incidence in Latin America.
Diogo de Freitas Paiva, Ana Paula dos Santos Matos, Denise de Abreu Garófalo, Tatielle do Nascimento, Mariana Sato de Souza de Bustamante Monteiro, Ralph Santos-Oliveira, Eduardo Ricci-Junior   +6 more
doaj   +1 more source

Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss. [PDF]

, 2021
Objectives/hypothesisTo examine the hearing outcomes of patients with sudden sensorineural hearing loss (SSNHL) treated with oral and intratympanic (IT) steroid only or a combination of steroid and migraine treatment.
Abouzari, Mehdi, Chua, Janice T, Djalilian, Hamid R, Goshtasbi, Khodayar, Lin, Harrison W, Saber, Tina, Sarna, Brooke, Tan, Donald   +7 more
core   +1 more source

Role of efficacy as a determinant of locomotor activation by mu‐opioid receptor (MOR) ligands in female and male mice. II. Effects of novel MOR‐selective phenylmorphans with high‐to‐low MOR efficacy

Pharmacology Research & Perspectives, 2023
Low‐efficacy mu‐opioid receptor (MOR) agonists represent promising therapeutics, but existing compounds (e.g., buprenorphine, nalbuphine) span a limited range of low MOR efficacies and have poor MOR selectivity.
Edna J. Santos, Nima Nassehi, Eric W. Bow, Dana R. Chambers, Eugene S. Gutman, Arthur E. Jacobson, Joshua A. Lutz, Samuel A. Marsh, Kenner C. Rice, Agnieszka Sulima, Dana E. Selley, S. Stevens Negus   +11 more
doaj   +1 more source

Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

Biomolecules, 2021
The dopamine D2/D3 receptor (D2R/D3R) agonists are used as therapeutics for Parkinson’s disease (PD) and other motor disorders. Selective targeting of D3R over D2R is attractive because of D3R’s restricted tissue distribution with potentially fewer side ...
Pramisha Adhikari, Bing Xie, Ana Semeano, Alessandro Bonifazi, Francisco O. Battiti, Amy H. Newman, Hideaki Yano, Lei Shi   +7 more
doaj   +1 more source

Stakeholder perceptions of lethal means safety counseling: A qualitative systematic review

Frontiers in Psychiatry, 2022
IntroductionLethal means safety counseling (LMSC) is an evidence-based suicide prevention intervention during which providers encourage patients to limit their access to lethal means (e.g., firearms, medications).
Gabriela Kattan Khazanov, Shimrit Keddem, Shimrit Keddem, Katelin Hoskins, Karoline Myhre, Sarah Sullivan, Emily Mitchell, Brooke Dorsey Holliman, Sara J. Landes, Sara J. Landes, Joseph Simonetti, Joseph Simonetti   +11 more
doaj   +1 more source

Acute Heart Failure Is a Malignant Process: But We Can Induce Remission

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Acute heart failure is a common and increasingly prevalent condition, affecting >10 million people annually. For those patients who survive to discharge, early readmissions and death rates are >30% everywhere on the planet, making it a malignant ...
Gad Cotter, Beth A. Davison, Carolyn S. P. Lam, Marco Metra, Piotr Ponikowski, John R. Teerlink, Alexandre Mebazaa   +6 more
doaj   +1 more source

Oral diabetes medication monotherapy and short-term mortality in individuals with type 2 diabetes and coronary artery disease [PDF]

, 2018
Objective To determine whether sulfonylurea use, compared with non-sulfonylurea oral diabetes medication use, was associated with 2-year mortality in individuals with well-controlled diabetes and coronary artery disease (CAD). Research design and methods
Berkowitz, Seth A, Caplan, Liron, Grunwald, Gary K, Liu, Wenhui G, Maddox, Thomas M, Raghavan, Sridharan, Reusch, Jane E.B, Saxon, David R   +7 more
core   +3 more sources

Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats

Cell Reports, 2017
Cocaine users show reduced expression of the metabotropic glutamate receptor (mGluR2), but it is not clear whether this is a predisposing trait for addiction or a consequence of drug exposure.
Hong-Ju Yang, Hai-Ying Zhang, Guo-Hua Bi, Yi He, Jun-Tao Gao, Zheng-Xiong Xi   +5 more
doaj   +1 more source

Comparison of osteoporosis pharmacotherapy fracture rates: Analysis of a marketScan® claims database cohort [PDF]

, 2018
Background: Several different classes of medications have been shown to be efficacious at preventing fractures in patients with osteoporosis. No study has compared real world efficacy at preventing fractures between all currently approved medications ...
Fox, Edward J., Kocis, Paul T., Leslie, Douglas L., Liu, Guodong, Reynolds, Alan W., Skowronski, Jenna N.   +5 more
core   +2 more sources