Results 111 to 120 of about 1,923,096 (295)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Type 1 Narcolepsy in Pregnancy: A Case Report and Review of Literature

American Journal of Perinatology Reports
Background Type 1 narcolepsy (with cataplexy) is a rare disorder affecting the central nervous system and is characterized by the inability to control sleep–wake cycles. There is a paucity of data regarding management during pregnancy.
Asnat Yuabov, Alexandra Kilinsky, Dina El Kady   +2 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A new taxonomy for describing and defining adherence to medications.

British Journal of Clinical Pharmacology, 2012
B. Vrijens, S. D. Geest, S. D. Geest, D. Hughes, Kardas Przemyslaw, J. Demonceau, Todd M. Ruppar, Todd M. Ruppar, F. Dobbels, E. Fargher, V. Morrison, P. Lewek, Michał Matyjaszczyk, C. Mshelia, W. Clyne, J. Aronson, J. Urquhart   +16 more
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Navigating Pregnancy Testing in Chronic Pain Management for Women of Reproductive Age

Journal of Pain Research
Shoran Tamura,1 Swarnima Vardhan,2 Kathryn Breidenbach,3 Naum Shaparin,3 Amaresh Vydyanathan,3 Karina Gritsenko3 1Department of Anesthesiology, Columbia University, New York, NY, USA; 2Department of Anesthesiology, Yale New Haven Health/Bridgeport ...
Tamura S, Vardhan S, Breidenbach K, Shaparin N, Vydyanathan A, Gritsenko K   +5 more
doaj  

ON CRIMINAL LIABILITY FOR ADULTERATED MEDICATIONS

Russian Journal of Economics and Law, 2011
Having studied the circulation of adulterrated medications in Russia, the author has stated that in prractice these actions are qualified by the Russian Criminal Code not uniformly, and grounded including into the Russian Crimianal Code of the Artice 238.
Y. Klyushkina
doaj  

Prediagnosis Insights Into Amyotrophic Lateral Sclerosis: Clinical Symptoms and Medication Use

Journal of Cachexia, Sarcopenia and Muscle
Background Amyotrophic lateral sclerosis (ALS) has a prolonged latency period, though its preclinical characteristics remain poorly understood. This study uses UK Biobank data to explore and compare ALS's pre‐diagnostic features, including symptoms and ...
Chunyang Pang, Wen Cao, Jiali Xie, Yaojia Li, Luyi Zhu, Huan Yu, Dongsheng Fan, Binbin Deng   +7 more
doaj   +1 more source

Identification of the consumption of medications that increase the risk of falls in hospitalized patients

O Mundo da Saúde
Falls represent a significant public health issue due to their high prevalence and physical, psychological, and social impacts. Medications that affect balance and motor coordination are modifiable risk factors associated with an increased incidence of ...
Ana Luiza Cardoso Rocha, Lariene Pires de Souza Rocha Santos, Elaine Ferreira Dias, Aline Manacés Souto Dias, Carla Jorge Machado, Josiane Moreira da Costa   +5 more
doaj   +1 more source