Results 21 to 30 of about 14,941 (270)
Stem Cell Research & Therapy, 2018 Background Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and to suppress immune response raises ...
Flavia Bruna +4 more
doaj +1 more source
Caveolin‐1 influences mitochondrial plasticity and function in hepatic stellate cell activation
Cell Biology International, Volume 46, Issue 11, Page 1787-1800, November 2022., 2022 Abstract Caveolin‐1 (Cav‐1) is an integral membrane protein present in all organelles, responsible for regulating and integrating multiple signals as a platform. Mitochondria are extremely adaptable to external cues in chronic liver diseases, and expression of Cav‐1 may affect mitochondrial flexibility in hepatic stellate cells (HSCs) activation.
Mariana Ilha +12 more
wiley +1 more source
Engineering in Life Sciences, Volume 22, Issue 10, Page 619-633, October 2022., 2022 Abstract The combined effect of surface topography and substrate rigidity in stem cell cultures is still under‐investigated, especially when biodegradable polymers are used. Herein, we assessed human bone marrow stem cell response on aliphatic polyester substrates as a function of anisotropic grooved topography and rigidity (7 and 12 kPa).
Sofia Ribeiro +8 more
wiley +1 more source
Stem Cells International, 2021 Mesenchymal stem cells (MSC) are adult multi-potent cells that can be isolated from many types of tissues including adipose tissue, bone marrow, and umbilical cord.
Sarah Ezquerra +5 more
doaj +1 more source
Cell Death and Disease, 2022 Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine for anabolic growth and survival.
Rosario Yerbes +5 more
doaj +1 more source
Type I collagen hydrogels as a delivery matrix for royal jelly derived extracellular vesicles
Drug Delivery, 2020 Throughout the last decade, extracellular vesicles (EVs) have become increasingly popular in several areas of regenerative medicine. Recently, Apis mellifera royal jelly EVs (RJ EVs) were shown to display favorable wound healing properties such as ...
Orlando J. Ramírez +5 more
doaj +1 more source
Scientific Reports, 2021 Granulocyte colony–stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly ...
Sandra Torres Galván +12 more
doaj +1 more source
Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency
Stem Cell Research, 2016 Little is known about the functions of downstream regulatory element antagonist modulator (DREAM) in embryonic stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a Ca2+-dependent manner, preventing CREB ...
A. Fontán-Lozano +6 more
doaj +1 more source
Técnicas del futuro: ingeniería de tejidos y uso de células madre en medicina reproductiva
Revista Médica Clínica Las Condes, 2010 Últimamente ha cobrado gran interés en la comunidad médica y científica, el avance experimentado por la medicina regenerativa, la ingeniería de tejidos y el uso de terapias celulares en base a células autólogas maduras, como también el uso de células ...
V. Cecilia Fabres, Dra.
doaj +1 more source
Nature Communications, 2020 The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies.
Alejandro Álvarez-Quilón +10 more
doaj +1 more source