Results 51 to 60 of about 14,941 (270)

Las células mesenquimales y sus vesículas extracelulares. Una propuesta alterna en el manejo inmunoregulador y regenerativo en pacientes con psoriasis

Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica
La psoriasis es una enfermedad crónica inflamatoria que afecta el 2 a 3 % de la población mundial, se produce por una activación anormal del sistema inmune principalmente por las vía IL23 / Th17 y la IL12 /Th1 generando una hiperproliferación de los ...
Luz Mabel Avila Portillo, Laura Ximena Rojas-Arévalo, Luis Antonio Castro   +2 more
doaj   +1 more source

Both CD133 Cells and Monocytes Provide Significant Improvement for Hindlimb Ischemia, Although They do not Transdifferentiate Into Endothelial Cells

Cell Transplantation, 2010
To address a number of questions regarding the experimental use of bone marrow (BM) stem cells in hindlimb ischemia, including which is the best cell type (e.g., purified hematopoietic stem cell or monocytes), the best route of delivery [intramuscular ...
Fermin M. Sanchez-Guijo M.D., PhD., Enrique Oterino, Maria-Victoria Barbado, Soraya Carrancio, Natalia Lopez-Holgado, Sandra Muntion, Pilar Hernandez-Campo, Luis-Ignacio Sanchez-Abarca, Jose A. Perez-Simon, Jesús F. San Miguel, Jesús G. Briñon, Maria-Consuelo Del Cañizo   +11 more
doaj   +1 more source

Role of the YAP/TAZ-TEAD Transcriptional Complex in the Metabolic Control of TRAIL Sensitivity by the Mevalonate Pathway in Cancer Cells

Cells, 2023
Different studies have reported that inhibiting the mevalonate pathway with statins may increase the sensitivity of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), although the signaling mechanism leading to this ...
Younes El Yousfi, Rocío Mora-Molina, Abelardo López-Rivas, Rosario Yerbes   +3 more
doaj   +1 more source

The CDK12–BRCA1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence

Molecular Oncology, Volume 19, Issue 4, Page 1265-1280, April 2025.
Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores, Diego M. Fernández‐Aroca, Cristina Garnés‐García, Andrés Domínguez‐Calvo, Jaime Jiménez‐Suárez, Sebastià Sabater, Pablo Fernández‐Aroca, Ignacio Andrés, Francisco J. Cimas, Guillermo de Cárcer, Borja Belandia, Ignacio Palmero, Pablo Huertas, María José Ruiz‐Hidalgo, Ricardo Sánchez‐Prieto   +14 more
wiley   +1 more source

Human predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion

Stem Cell Research & Therapy, 2019
Background Human decidual stromal cells (DSCs) are involved in the maintenance and development of pregnancy, in which they play a key role in the induction of immunological maternal–fetal tolerance.
Raquel Muñoz-Fernández, Claudia De La Mata, Francisco Requena, Francisco Martín, Pablo Fernandez-Rubio, Tatiana Llorca, Maria José Ruiz-Magaña, Carmen Ruiz-Ruiz, Enrique G. Olivares   +8 more
doaj   +1 more source

The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts

Nature Communications, 2023
Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication conflicts (TRCs).
Aleix Bayona-Feliu, Emilia Herrera-Moyano, Nibal Badra-Fajardo, Iván Galván-Femenía, María Eugenia Soler-Oliva, Andrés Aguilera   +5 more
doaj   +1 more source

Evaluación de la citotoxicidad y genotoxicidad in vitro de biomateriales basados en Polietilenglicol- Quitosano [PDF]

, 2017
La medicina regenerativa es la ciencia que tiene como objetivo reemplazar o regenerar células humanas, tejidos u órganos, para restaurar o establecer una función normal.
GARIBAY GARCIA, JIMENA, GARIBAY GARCIA, JIMENA   +1 more
core  

Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance

Molecular Oncology, Volume 19, Issue 3, Page 592-613, March 2025.
Glioblastoma is one of the most lethal human cancers with no effective treatment nowadays. Here, we review the increasing amount of evidence supporting the connection between cell signaling deregulation and metabolic reprogramming as a key event in glioblastoma resistance to cancer therapy.
Laura Zarzuela, Raúl V. Durán, Mercedes Tomé   +2 more
wiley   +1 more source

El sujeto ante la dignidad. Algunos aspectos éticos de las IPS y su posible desarrollo investigador. [PDF]

, 2008
La declaración del 48 con su referencia a la dignidad humana buscaba en su linea principal eliminar la capacidad de discriminación legal entre hombres plenamente humanos y hombres no humanos o subhumanos. El proceso ha tenido un éxito fundamental pero
Serrano, J.M. (José Miguel)
core  

Terapia regenerativa en tendones y células madres en medicina equina [PDF]

, 2013
Se ha realizado extensa investigación clínica con células madre en el equino, siendo una fuente de estudios vanguardistas en medicina veterinaria, así como un modelo animal excepcional.
Arias F., J. Ignacio, Beato, Carolina
core   +2 more sources