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Medicinal Chemistry of Isocyanides [PDF]

open access: yesChemical Reviews, 2021
In eons of evolution, isocyanides carved out a niche in the ecological systems probably thanks to their metal coordinating properties. In 1859 the first isocyanide was synthesized by humans and in 1950 the first natural isocyanide was discovered. Now, at the beginning of XXI century, hundreds of isocyanides have been isolated both in prokaryotes and ...
Alberto Massarotti   +4 more
openaire   +6 more sources

Heterocycles in Medicinal Chemistry [PDF]

open access: yesMolecules, 2019
Heteroatoms constitute a very common fragment of a number of active pharmaceutical ingredients as well as excipients; from the point of view of significance, it is all the same if these are isosterically/bioisosterically replaced carbons/carbon ...
Josef Jampilek
doaj   +3 more sources

Molecular Filters in Medicinal Chemistry

open access: yesEncyclopedia, 2023
Efficient chemical library design for high-throughput virtual screening and drug design requires a pre-screening filter pipeline capable of labeling aggregators, pan-assay interference compounds (PAINS), and rapid elimination of swill (REOS); identifying
Sebastjan Kralj   +2 more
doaj   +2 more sources

Feature Reviews in Medicinal Chemistry [PDF]

open access: yesPharmaceuticals
This Special Issue of Pharmaceuticals (“Feature reviews in Medicinal Chemistry”) contains a series of reviews covering a broad selection of topics in Medicinal Chemistry, which are chosen to illustrate important recent results in this fast-evolving ...
Mary J. Meegan
doaj   +2 more sources

Heterocycles in Medicinal Chemistry II [PDF]

open access: yesMolecules
Carbon has a unique position among the elements, due to the fact that its valence shell has four electrons and is therefore quadrivalent in the excited state [...]
Josef Jampilek
doaj   +2 more sources

Medicinal Chemistry

open access: yesCHIMIA, 2007
Swiss Chemical Society
doaj   +3 more sources

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