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Molecules, 2021 During the last few decades, pyridazine derivatives have emerged as privileged structures in heterocyclic chemistry, both because of their excellent chemistry and because of their potential applications in medicinal chemistry and optoelectronics.
Dorina Amariucai-Mantu +2 more
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Essential Medicinal Chemistry of Essential Medicines [PDF]
Journal of Medicinal Chemistry, 2020 Since 1977, the World Health Organization publishes a list of essential medicines, i.e., those that satisfy the priority health care needs of the population and are selected with regard to disease prevalence and public health relevance, evidence of clinical efficacy, and safety, as well as comparative costs and cost-effectiveness.
Marta Serafini +4 more
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Oxetanes: Recent Advances in Synthesis, Reactivity and Medicinal Chemistry [PDF]
, 2016 The 4-membered oxetane ring has been increasingly exploited for its behaviors, i.e. influence on physicochemical properties as a stable motif in medicinal chemistry, and propensity to undergo ring opening reactions as a synthetic intermediate.
Bull, JA +4 more
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Looking back and moving forward in medicinal chemistry
Nature Communications, 2023 Medicinal chemistry is a fast-evolving interdisciplinary research area which aims to improve human life by developing drugs to combat diseases. Nature Communications interviewed three scientists, Daniele Castagnolo (Associate Professor at University ...
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Development of Advanced Macrosphelides: Potent Anticancer Agents
Molecules, 2015 Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography ...
Seung-Mann Paek
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Metal Complexes and Medicine: A Successful Combination
CHIMIA, 2015 Since the start of our independent research at the Department of Chemistry of the University of Zurich in 2009, our group has been, among other topics, working on the use of metal complexes in medicinal chemistry.
Gilles Gasser
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An Element of Community: EFMC, the European Federation for Medicinal Chemistry
CHIMIA, 2019 The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society is an active member of the European Federation for Medicinal Chemistry (EFMC), whose mission is to advance the science of medicinal chemistry in Europe. EFMC promotes
Yves P. Auberson
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BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology. [PDF]
, 2015 BindingDB, www.bindingdb.org, is a publicly accessible database of experimental protein-small molecule interaction data. Its collection of over a million data entries derives primarily from scientific articles and, increasingly, US patents.
Baitaluk, Michael +5 more
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Reductive cleavage of sulfones and sulfonamides by neutral organic super electron-donor (S.E.D.) reagent [PDF]
, 2007 The sulfonyl group finds extensive applications in organic and medicinal chemistry both in sulfonamides, popular as robust protecting groups for amines, and in sulfones.
Miclo, Yves +5 more
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