Results 11 to 20 of about 1,560,516 (389)

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

Pharmaceuticals, 2023
Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance.
Adarsh Kumar, A. Singh, Harshwardhan Singh, Veena Vijayan, Deepak Kumar, Jashwanth Naik, Suresh Thareja, Jagat Pal Yadav, Prateek Pathak, M. Grishina, A. Verma, Habibullah Khalilullah, Mariusz Jaremko, A. Emwas, Pradeep Kumar   +14 more
semanticscholar   +1 more source

Revolutionizing Medicinal Chemistry: The Application of Artificial Intelligence (AI) in Early Drug Discovery

Pharmaceuticals, 2023
Artificial intelligence (AI) has permeated various sectors, including the pharmaceutical industry and research, where it has been utilized to efficiently identify new chemical entities with desirable properties.
Ri Han, Hongryul Yoon, Gahee Kim, Hyundo Lee, Yoonji Lee   +4 more
semanticscholar   +1 more source

The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry

Pharmaceuticals, 2022
In this review, the history of boron’s early use in drugs, and the history of the use of boron functional groups in medicinal chemistry applications are discussed. This includes diazaborines, boronic acids, benzoxaboroles, boron clusters, and carboranes.
Katia Messner, Billy Vuong, G. Tranmer
semanticscholar   +1 more source

[3 + n] Cycloaddition Reactions: A Milestone Approach for Elaborating Pyridazine of Potential Interest in Medicinal Chemistry and Optoelectronics

Molecules, 2021
During the last few decades, pyridazine derivatives have emerged as privileged structures in heterocyclic chemistry, both because of their excellent chemistry and because of their potential applications in medicinal chemistry and optoelectronics.
Dorina Amariucai-Mantu, Violeta Mangalagiu, Ionel I. Mangalagiu   +2 more
doaj   +1 more source

Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry.

ACS Medicinal Chemistry Letters, 2022
Carboxylic acids, the most versatile and ubiquitous diversity input used in medicinal chemistry for canonical polar bond constructions such as amide synthesis, can now be employed in a fundamentally different category of reaction to make C-C bonds by ...
G. Laudadio, Maximilian D Palkowitz, T. Ewing, P. Baran   +3 more
semanticscholar   +1 more source

Recent Advances of Pyridinone in Medicinal Chemistry

Frontiers in Chemistry, 2022
Pyridinones have been adopted as an important block in medicinal chemistry that could serve as hydrogen bond donors and acceptors. With the help of feasible synthesis routes via established condensation reactions, the physicochemical properties of such a
Shibo Lin, Chun Liu, Xiaotian Zhao, Xiao-Jie Han, Xuanhao Li, Y. Ye, Zheyu Li   +6 more
semanticscholar   +1 more source

Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach

Chemical Reviews, 2021
The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and parasitic pathogens. Recognition of these unique glycans by the human immune system results in destruction of the invaders.
P. Seeberger
semanticscholar   +1 more source

Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications

ACS Omega, 2021
Since the approval of three hydroxamic acid-based HDAC inhibitors as anticancer drugs, such functional groups acquired even more notoriety in synthetic medicinal chemistry.
A. Citarella, D. Moi, Luca Pinzi, D. Bonanni, G. Rastelli   +4 more
semanticscholar   +1 more source

Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis.

RSC Medicinal Chemistry, 2021
Urea and thiourea represent privileged structures in medicinal chemistry. Indeed, these moieties constitute a common framework of a variety of drugs and bioactive compounds endowed with a broad range of therapeutic and pharmacological properties. Herein,
Riccardo Ronchetti, Giada Moroni, A. Carotti, A. Gioiello, E. Camaioni   +4 more
semanticscholar   +1 more source

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

Scientific Reports, 2017
To be effective as a drug, a potent molecule must reach its target in the body in sufficient concentration, and stay there in a bioactive form long enough for the expected biologic events to occur.
Antoine Daina, O. Michielin, V. Zoete
semanticscholar   +1 more source