Results 11 to 20 of about 1,547,751 (329)

Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach

Chemical Reviews, 2021
The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and parasitic pathogens. Recognition of these unique glycans by the human immune system results in destruction of the invaders.
P. Seeberger
semanticscholar   +1 more source

Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications

ACS Omega, 2021
Since the approval of three hydroxamic acid-based HDAC inhibitors as anticancer drugs, such functional groups acquired even more notoriety in synthetic medicinal chemistry.
A. Citarella, D. Moi, Luca Pinzi, D. Bonanni, G. Rastelli   +4 more
semanticscholar   +1 more source

Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis.

RSC Medicinal Chemistry, 2021
Urea and thiourea represent privileged structures in medicinal chemistry. Indeed, these moieties constitute a common framework of a variety of drugs and bioactive compounds endowed with a broad range of therapeutic and pharmacological properties. Herein,
Riccardo Ronchetti, Giada Moroni, A. Carotti, A. Gioiello, E. Camaioni   +4 more
semanticscholar   +1 more source

Put a ring on it: application of small aliphatic rings in medicinal chemistry.

RSC Medicinal Chemistry, 2021
Aliphatic three- and four-membered rings including cyclopropanes, cyclobutanes, oxetanes, azetidines and bicyclo[1.1.1]pentanes have been increasingly exploited in medicinal chemistry for their beneficial physicochemical properties and applications as ...
M. Bauer, Paolo Di Fruscia, S. Lucas, Iacovos N Michaelides, Jennifer E Nelson, R. I. Storer, Benjamin C. Whitehurst   +6 more
semanticscholar   +1 more source

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

Scientific Reports, 2017
To be effective as a drug, a potent molecule must reach its target in the body in sufficient concentration, and stay there in a bioactive form long enough for the expected biologic events to occur.
Antoine Daina, O. Michielin, V. Zoete
semanticscholar   +1 more source

Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective

International Journal of Molecular Sciences, 2021
In the past few years, Bruton’s tyrosine Kinase (Btk) has emerged as new target in medicinal chemistry. Since approval of ibrutinib in 2013 for treatment of different hematological cancers (as leukemias and lymphomas), two other irreversible Btk ...
C. Brullo, Carla Villa, B. Tasso, E. Russo, A. Spallarossa   +4 more
semanticscholar   +1 more source

The Cu(OTf)2 catalysed microwave assisted synthesis of a new scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one [PDF]

, 2014
The synthesis of novel 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-ones is described including a one-step Mannich-type reaction followed by intramolecular ring closure of ethyl 3-methylpyridazine-4- carboxylate and aldimines, catalysed by the Lewis ...
De Coen, Laurens, Jatczak, Martyna, Mangelinckx, Sven, Muylaert, Koen, Stevens, Christian, Van Hecke, Kristof   +5 more
core   +2 more sources

Oxetanes: Recent Advances in Synthesis, Reactivity and Medicinal Chemistry [PDF]

, 2016
The 4-membered oxetane ring has been increasingly exploited for its behaviors, i.e. influence on physicochemical properties as a stable motif in medicinal chemistry, and propensity to undergo ring opening reactions as a synthetic intermediate.
Bull, JA, Croft, RA, Davis, OA, Doran, R, Morgan, KF   +4 more
core   +1 more source

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs [PDF]

, 2009
This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging.
Aird, Ang, Barnard, Barnes, Bednarski, Bergamo, Bergamo, Bindoli, Campone, Chatterjee, Che, Chen, Chen, Chen, Chen, Choy, Clarke, Cordier, Desoize, Detty, Dougan, Ernst, Failes, Farrer, Feazell, Fricker, Gabbiani, Gunatilleke, Hall, Hambley, Hamelers, Henderson, Hillard, Hotze, Hotze, Jakupec, Jakupec, Junicke, Kelland, Kostenich, Kostova, Kostrhunova, Li, Mackay, Mackay, Meggers, Mosi, Nguyen, Noor, Oliveira, Ott, Ott, Ott, Peacock, Peacock, Peacock, Peter J. Sadler, Petzold, Petzold, Powis, Rademaker-Lakhai, Sabine H. van Rijt, Sadler, Saggioro, Sergeant, Sessler, Sharman, Shaw, Sherman, Smalley, Storr, Urig, van Rijt, Vessieres, Wang, Wang   +75 more
core   +1 more source

Looking back and moving forward in medicinal chemistry

Nature Communications, 2023
Medicinal chemistry is a fast-evolving interdisciplinary research area which aims to improve human life by developing drugs to combat diseases. Nature Communications interviewed three scientists, Daniele Castagnolo (Associate Professor at University ...
doaj   +1 more source