Results 241 to 250 of about 390,146 (300)
Imidazole Hybrids: A Privileged Class of Heterocycles in Medicinal Chemistry with New Insights into Anticancer Activity. [PDF]
MoleculesMurtazaeva Z +10 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto +5 more
wiley +1 more source
Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry. [PDF]
MoleculesDe Filippis B +7 more
europepmc +1 more source
Most autophagic cell death studies lack evidence of causality
FEBS Open Bio, EarlyView.Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley +1 more source
Pyrazolo[5,1-<i>c</i>][1,2,4]triazole: A Promising Emerging Biologically Active Scaffold in Medicinal Chemistry. [PDF]
Int J Mol SciPintea BN +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki +3 more
wiley +1 more source