Results 251 to 260 of about 376,307 (328)

Session Medicinal Chemistry & Chemical Biology

CHIMIA, 2022
Céline Wittwer
doaj  

Structural insights, regulation, and recent advances of RAS inhibitors in the MAPK signaling cascade: a medicinal chemistry perspective. [PDF]

RSC Med Chem
Prajapati V, Singh AK, Kumar A, Singh H, Pathak P, Grishina M, Kumar V, Khalilullah H, Verma A, Kumar P.   +9 more
europepmc   +1 more source

Synthetic Approaches, Properties, and Applications of Acylals in Preparative and Medicinal Chemistry. [PDF]

Molecules
Keydel T, Link A.
europepmc   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Syntheses and medicinal chemistry of spiro heterocyclic steroids. [PDF]

Beilstein J Org Chem
Romero-Hernández LL, Ahuja-Casarín AI, Merino-Montiel P, Montiel-Smith S, Vega-Báez JL, Sandoval-Ramírez J.   +5 more
europepmc   +1 more source

Session Medicinal Chemistry & Chemical Biology

CHIMIA, 2020
David Spichiger
doaj  

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Session Medicinal Chemistry Chemical Biology

CHIMIA, 2018
David Spichiger
doaj   +2 more sources

Curcumin Derivatives in Medicinal Chemistry: Potential Applications in Cancer Treatment. [PDF]

Molecules
Kuzminska J, Szyk P, Mlynarczyk DT, Bakun P, Muszalska-Kolos I, Dettlaff K, Sobczak A, Goslinski T, Jelinska A.   +8 more
europepmc   +1 more source

The Medicinal Chemistry at the “Polo de Xistoquímica” of the IQ‐UFRJ

, 2009
Joaquim F.M. Silva, Biank T. Gonçalves, Gizelda de O. D. Estrada, Ricardo S. Yaunner, Lucas Villas Bôas Hoelz   +4 more
openalex   +1 more source