Results 251 to 260 of about 390,146 (300)

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Revolutionizing Playing with Skeleton Atoms: Molecular Editing Surgery in Medicinal Chemistry. [PDF]

Mini Rev Med Chem
Rabie AM.
europepmc   +1 more source

Curcumin Derivatives in Medicinal Chemistry: Potential Applications in Cancer Treatment

Joanna Kuźmińska, Piotr Szyk, Dariusz T. Młynarczyk, Paweł Bakun, Izabela Muszalska-Kolos, Katarzyna Dettlaff, Agnieszka Sobczak, Tomasz Gośliński, Anna Jelińska   +8 more
openalex   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

High-Risk Neuroblastoma Stage 4 (NBS4): Developing a Medicinal Chemistry Multi-Target Drug Approach. [PDF]

Molecules
Gerges A, Canning U.
europepmc   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source

Session Medicinal Chemistry & Chemical Biology

CHIMIA, 2015
David Spichiger
doaj   +2 more sources

Editorial: Medicinal chemistry for neglected tropical diseases using <i>in-vitro</i>, <i>in-vivo</i> and <i>in silico</i> approaches. [PDF]

Front Chem
Mali SN, Saied EM, Dos Santos CBR, Neves Cruz J.   +3 more
europepmc   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Design and Implementation of Interactive, Remote Online Escape Rooms in Medicinal Chemistry

Aisyah Saad Abdul Rahim, Kee-Man Chuah
openalex   +2 more sources