Results 271 to 280 of about 1,354,772 (332)
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Metallocyclodextrins in Medicinal Chemistry
Future Medicinal Chemistry, 2018This review focuses on metal complexes of cyclodextrin (CyD) derivatives designed for application as therapeutics or diagnostics. We discuss examples of metalloprotein models (hemoglobin, superoxide dismutase and catalase) based on cyclodextrins. The hydrophobic microenvironment of CyDs stabilizes the Fe(II) porphyrin system that can reversibly bind O2
Valentina Oliveri, Graziella Vecchio
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Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor.
Journal of Medicinal Chemistry, 2021Farnesoid X receptor (FXR) is an important regulator of bile acid, lipid, amino acid, and glucose homeostasis, hepatic inflammation, regeneration, and fibrosis.
Yuanying Fang +3 more
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Recent advancements on Benzimidazole: A versatile scaffold in medicinal chemistry.
Mini-Reviews in Medical Chemistry, 2021Benzimidazole is nitrogen containing fused heterocycle which has been extensively explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various biological activities such as anticancer, antimicrobial, anti-inflammatory ...
Zohor Mohammad Mahdi Alzhrani +2 more
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Chemical Reviews
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date, five BCC drugs (including boronic acids and boroles) have been approved by the FDA for the treatment of cancer, infections, and atopic dermatitis, while some natural BCC ...
R. Grams +8 more
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Boron-containing compounds (BCC) have emerged as important pharmacophores. To date, five BCC drugs (including boronic acids and boroles) have been approved by the FDA for the treatment of cancer, infections, and atopic dermatitis, while some natural BCC ...
R. Grams +8 more
semanticscholar +1 more source
Triazoles in Medicinal Chemistry: Physicochemical Properties, Bioisosterism, and Application.
Journal of Medicinal ChemistryTriazole demonstrates distinctive physicochemical properties, characterized by weak basicity, various dipole moments, and significant dual hydrogen bond acceptor and donor capabilities.
Qianwen Guan +9 more
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Furazans in Medicinal Chemistry.
Journal of Medicinal Chemistry, 2021Incorporation of heterocycles into drug molecules can enhance physical properties and biological activity. A variety of heterocyclic groups is available to medicinal chemists, many of which have been reviewed in detail elsewhere.
Ross S. Mancini +3 more
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Spirocyclic Scaffolds in Medicinal Chemistry.
Journal of Medicinal Chemistry, 2020Spirocyclic scaffolds are incorporated in various approved drugs and drug candidates. The increasing interest in less planar bioactive compounds has given rise to the development of synthetic methodologies for the preparation of spirocyclic scaffolds. In
K. Hiesinger +3 more
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Applications of Deuterium in Medicinal Chemistry.
Journal of Medicinal Chemistry, 2019The use of deuteration in medicinal chemistry has exploded in the past years, and the FDA has recently approved the first deuterium-labeled drug. Precision deuteration goes beyond the pure and simple amelioration of the pharmacokinetic parameters of a ...
T. Pirali +3 more
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Lipopeptides as tools in catalysis, supramolecular, materials and medicinal chemistry
Nature Reviews Chemistry, 2023César Vicente-García, Ignacio Colomer
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