Results 271 to 280 of about 376,307 (328)

Therapeutic Potential of Prenylated Flavonoids of the Fabaceae Family in Medicinal Chemistry: An Updated Review. [PDF]

Int J Mol Sci
Morante-Carriel J, Nájera H, Samper-Herrero A, Živković S, Martínez-Esteso MJ, Martínez-Márquez A, Sellés-Marchart S, Obrebska A, Bru-Martínez R.   +8 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Medicinal Chemistry of Drugs with N-Oxide Functionalities. [PDF]

J Med Chem
Kobus M, Friedrich T, Zorn E, Burmeister N, Maison W.   +4 more
europepmc   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Multitarget-Directed Ligands Hitting Serotonin Receptors: A Medicinal Chemistry Survey. [PDF]

Pharmaceuticals (Basel)
Ghafir El Idrissi I, Santo A, Lacivita E, Leopoldo M.   +3 more
europepmc   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Synthetic strategies and medicinal chemistry perspectives of dual acting carbonic anhydrase modulators with monoamine oxidase and cholinesterase inhibitors. [PDF]

RSC Med Chem
Bindra S, Mostafa EM, Abdelgawad MA, Selim S, Kumar S, Mathew B.   +5 more
europepmc   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual <i>Plasmodium</i> Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria. [PDF]

J Med Chem
Gachuhi S, Kamunya S, Fienberg S, Wambua L, Salomane N, Mayoka G, Taylor D, Coertzen D, van der Watt M, Reader J, Birkholtz LM, Wittlin S, Krugmann L, Coulson LB, Chibale K.   +14 more
europepmc   +1 more source