Medicinal Chemistry of Isocyanides.
Chemical Reviews, 2021 In eons of evolution, isocyanides carved out a niche in the ecological systems probably thanks to their metal coordinating properties. In 1859 the first isocyanide was synthesized by humans and in 1950 the first natural isocyanide was discovered. Now, at
A. Massarotti +4 more
semanticscholar +1 more source
Development of Advanced Macrosphelides: Potent Anticancer Agents
Molecules, 2015 Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography ...
Seung-Mann Paek
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Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors
Acta Pharmaceutica Sinica B, 2022 Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection. Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative ...
Shenghua Gao +11 more
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An Element of Community: EFMC, the European Federation for Medicinal Chemistry
CHIMIA, 2019 The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society is an active member of the European Federation for Medicinal Chemistry (EFMC), whose mission is to advance the science of medicinal chemistry in Europe. EFMC promotes
Yves P. Auberson
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Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics
ChemMedChem, 2020 The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming rate and has created an unprecedented health emergency around the globe.
Arun K. Ghosh +4 more
semanticscholar +1 more source
Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels [PDF]
, 2018 Drugs do not act solely by canonical ligand–receptor binding interactions. Amphiphilic drugs partition into membranes, thereby perturbing bulk lipid bilayer properties and possibly altering the function of membrane proteins.
Aldrich, Richard W. +12 more
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Metal Complexes and Medicine: A Successful Combination
CHIMIA, 2015 Since the start of our independent research at the Department of Chemistry of the University of Zurich in 2009, our group has been, among other topics, working on the use of metal complexes in medicinal chemistry.
Gilles Gasser
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Heterocycles in Medicinal Chemistry
Molecules, 2019 Heteroatoms constitute a very common fragment of a number of active pharmaceutical ingredients as well as excipients; from the point of view of significance, it is all the same if these are isosterically/bioisosterically replaced carbons/carbon ...
Josef Jampilek
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Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N -Diethyl-Substituted AmidoMoieties [PDF]
, 2012 Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities.
Ajani, Olayinka O. +4 more
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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7
Molecules, 2020 Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]
Michael Gütschow +47 more
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