Results 21 to 30 of about 1,354,772 (332)

Medicinal Chemistry: A Key Driver in Achieving the Global Sustainable Development Goals [PDF]

J Med Chem
Bianca Martinengo, Eleonora Diamanti, Elisa Uliassi, María Laura Bolognesi   +3 more
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Imidazole: Synthesis, Functionalization and Physicochemical Properties of a Privileged Structure in Medicinal Chemistry

Molecules, 2023
Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction of glyoxal and formaldehyde in ammonia, initially called glyoxaline.
H. Tolomeu, C. A. Fraga
semanticscholar   +1 more source

2-Phenethylamines in Medicinal Chemistry: A Review

Molecules, 2023
A concise review covering updated presence and role of 2-phenethylamines in medicinal chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are enumerated in key therapeutic targets, listing medicinal chemistry hits and ...
Carlos T. Nieto, Alejandro Manchado, Leland Belda, D. Díez, N. Garrido   +4 more
semanticscholar   +1 more source

Getting the Numbers Right in Medicinal Chemistry [PDF]

ChemMedChem
Christian Ducho
openalex   +2 more sources

Amino-Pyrazoles in Medicinal Chemistry: A Review

International Journal of Molecular Sciences, 2023
A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential. Consequently, the search for new pyrazole-based compounds is of great interest to the academic community as well as industry.
Matteo Lusardi, A. Spallarossa, C. Brullo   +2 more
semanticscholar   +1 more source

Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry.

ACS Medicinal Chemistry Letters, 2022
Carboxylic acids, the most versatile and ubiquitous diversity input used in medicinal chemistry for canonical polar bond constructions such as amide synthesis, can now be employed in a fundamentally different category of reaction to make C-C bonds by ...
G. Laudadio, Maximilian D Palkowitz, T. Ewing, P. Baran   +3 more
semanticscholar   +1 more source

The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry

Pharmaceuticals, 2022
In this review, the history of boron’s early use in drugs, and the history of the use of boron functional groups in medicinal chemistry applications are discussed. This includes diazaborines, boronic acids, benzoxaboroles, boron clusters, and carboranes.
Katia Messner, Billy Vuong, G. Tranmer
semanticscholar   +1 more source

Chalcone: A Privileged Structure in Medicinal Chemistry

Chemical Reviews, 2017
Chun-Lin Zhuang, Wen Zhang, Chunquan Sheng   +2 more
exaly   +2 more sources

Basic nitrogen (BaN): a ‘privileged element’ in medicinal chemistry [PDF]

Future Med Chem
Sandeep Sundriyal
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Recent Advances of Pyridinone in Medicinal Chemistry

Frontiers in Chemistry, 2022
Pyridinones have been adopted as an important block in medicinal chemistry that could serve as hydrogen bond donors and acceptors. With the help of feasible synthesis routes via established condensation reactions, the physicochemical properties of such a
Shibo Lin, Chun Liu, Xiaotian Zhao, Xiao-Jie Han, Xuanhao Li, Y. Ye, Zheyu Li   +6 more
semanticscholar   +1 more source