Results 71 to 80 of about 371,531 (327)
Sialic acids in biological and therapeutic processes: opportunities and challenges [PDF]
, 2015 It is now well documented that carbohydrates play multiple roles in biological processes, and hence are interesting targets for chemical biology and medicinal chemistry programmes.
Helen MI Osborn +3 more
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Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients
Molecular Oncology, EarlyView.Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha +6 more
wiley +1 more source
Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors
Acta Pharmaceutica Sinica B, 2022 Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection. Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative ...
Shenghua Gao +11 more
doaj
Why do Euphorbiaceae tick as medicinal plants? : a review of Euphorbiaceae family and its medicinal features [PDF]
, 2011 Euphorbiaceae is among the large flowering plant families consisting of a wide variety of vegetative forms some of which are plants of great importance. Its classification and chemistry have of late been subjects of interest possibly because of the wide ...
Mwine, Tedson Julius, Van Damme, Patrick
core
A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini +11 more
wiley +1 more source
Medicinal Chemistry: A Teacher's and Worker's Perspective
CHIMIA, 1992 This personal commentary aims at offering a description of the origin, purpose, and methods of medicinal chemistry, and a delineation of its fields of activity in connection with related sciences.
Bernard Testa
doaj +2 more sources
Similarity-based virtual screening using 2D fingerprints [PDF]
, 2006 This paper summarises recent work at the University of Sheffield on virtual screening methods that use 2D fingerprint measures of structural similarity. A detailed comparison of a large number of similarity coefficients demonstrates that the well-known ...
Willett, P.
core +1 more source
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Molecular Oncology, EarlyView.Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi +6 more
wiley +1 more source
Small Molecules in Development for the Treatment of Spinal Muscular Atrophy [PDF]
, 2016 Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease resulting from pathologically low levels of survival motor neuron (SMN) protein.
Androphy, Elliot J. +2 more
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Open Medicinal Chemistry [PDF]
ChemMedChem, 2018 Hello 2019! ChemMedChem Editor David Peralta looks back at the journal's activities in 2018, as well as upcoming Special Collections, features, and developments for ChemPubSoc Europe in 2019. He also introduces the journal's new Editorial Board co-chair, Prof. Sangyong Jon from the Korea Advanced Institute of Science and Technology (KAIST).
openaire +3 more sources