Results 71 to 80 of about 214,287 (302)

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Mediterranean diet adherence and epilepsy: the mediating role of stroke based on a cross-sectional study

European Journal of Medical Research
Background Epilepsy is a neurological disorder that can affect individuals of all genders and ages. Recent studies have indicated that the Mediterranean diet exerts a neuroprotective effect through its anti-inflammatory and antioxidant properties in non ...
Mingjing Zhou, Xuyan Zhao, Peinan Liu, Xiangwei Hou, Yiyang Cao, Maode Wang, Jia Wang   +6 more
doaj   +1 more source

Eating Pattern Response to a Low-Fat Diet Intervention and Cardiovascular Outcomes in Normotensive Women: The Women's Health Initiative. [PDF]

, 2020
BackgroundWomen without cardiovascular disease (CVD) or hypertension at baseline assigned to intervention in the Women's Health Initiative Dietary Modification (DM) trial experienced 30% lower risk of coronary heart disease (CHD), whereas results in ...
Allison, Matthew A, Aragaki, Aaron K, Howard, Barbara V, Isasi, Carmen R, Manson, JoAnn E, Mossavar-Rahmani, Yasmin, Neuhouser, Marian L, Prentice, Ross L, Thomson, Cynthia A, Van Horn, Linda, Vitolin, Mara Z, Wallace, Robert B, WHI Investigators   +12 more
core   +1 more source

The impacts of biological invasions

Biological Reviews, EarlyView.
ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock, Teun Everts, Neil Angelo S. Abreo, Jamie Bojko, Victor Deklerck, James W. E. Dickey, Ana Clara S. Franco, Emili García‐Berthou, Stelios Katsanevakis, Natalia I. Kirichenko, Stefano Mammola, Martin A. Nuñez, Ben Parker, Riccardo Scalera, Ismael Soto, Diederik Strubbe, Ali Serhan Tarkan, Lorenzo Vilizzi, Tim Adriaens, Paride Balzani, Dagmara Błońska, Elizabeta Briski, Rein Brys, Amy L. Burgess, James E. Byers, Carlos Cano‐Barbacil, Giuseppe Castaldelli, Jaimie T.A. Dick, Victoria Dominguez Almela, Romina D. Dimarco, Margarita Florencio, Antonín Kouba, Melina Kourantidou, Irmak Kurtul, Irene Martín‐Forés, Olivier Morissette, Julian D. Olden, Bruno E. Soares, Jakub Truszkowski, Hugo Verreycken, Marc Kenis, Ronaldo Sousa, J. Robert Britton   +42 more
wiley   +1 more source

The influence of rivers on seabird foraging ecology

Biological Reviews, EarlyView.
ABSTRACT Rivers act as vital arteries to the world's oceans, delivering fresh water and nutrients that sustain marine ecosystems. Globally, river flow increasingly is being altered by climate change and anthropogenic pressures; yet the significance of rivers to predatory marine species, such as seabirds, and the extent to which river‐related changes ...
Julia B. Morais, Andre Chiaradia, Richard D. Reina   +2 more
wiley   +1 more source

A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses

BMJ Open, 2015
Objectives To summarise the evidence about the efficacy of a Mediterranean diet on the management of type 2 diabetes and prediabetic states.Design A systematic review of all meta-analyses and randomised controlled trials (RCTs) that compared the ...
Demosthenes Panagiotakos, Katherine Esposito, Paolo Chiodini, Maria Ida Maiorino, Giuseppe Bellastella, Dario Giugliano   +5 more
doaj   +1 more source

Mediterranean diet and longevity

British Journal Of Nutrition, 2000
Mortality statistics from the WHO database covering the period 1960 to 1990 have provided intriguing evidence that something unusual has been affecting in a beneficial way the health of the Mediterranean population. In recent papers, which evaluated the evidence accumulated over the last three decades, it was concluded that the traditional ...
Trichopoulou, A., Vasilopoulou, E.
openaire   +3 more sources

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Yearly attained adherence to Mediterranean diet and incidence of diabetes in a large randomized trial

Cardiovascular Diabetology, 2023
Background Several large observational prospective studies have reported a protection by the traditional Mediterranean diet against type 2 diabetes, but none of them used yearly repeated measures of dietary intake. Repeated measurements of dietary intake
Miguel A. Martínez-González, Pedro Montero, Miguel Ruiz-Canela, Estefanía Toledo, Ramón Estruch, Enrique Gómez-Gracia, Jun Li, Emilio Ros, Fernando Arós, Alvaro Hernáez, Dolores Corella, Miquel Fiol, José Lapetra, Lluis Serra-Majem, Xavier Pintó, Montse Cofán, José V. Sorlí, Nancy Babio, Yolanda F. Márquez-Sandoval, Olga Castañer, Jordi Salas-Salvadó   +20 more
doaj   +1 more source

Why The Mediterranean Diet?

Journal of Education, Health and Sport, 2018
Chudzińska Małgorzata, Nartowicz Małgorzata, Zukow Walery, Sinkiewicz Władysław. Why the Mediterranean diet? Journal of Education, Health and Sport. 2018;8(10):326-337. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1489258 http://ojs.ukw.edu.pl/index.phpohs/article/view/6302 https://pbn.nauka.gov.pl/sedno-webapp/works/887410 ...
Chudzińska, Małgorzata, Nartowicz, Małgorzata, Żukow, Walery, Sinkiewicz, Władysław   +3 more
openaire   +5 more sources