Results 91 to 100 of about 732,819 (307)

Attitudes of isiXhosa-speaking students at the University of Fort Hare towards the use of isiXhosa as a language of learning and teaching (LOLT) [PDF]

open access: yes, 2004
The present work presents and discusses the results of a survey of a sample of isiXhosa-speaking students at the University of Fort Hare (Alice campus) and their attitudes towards the possible introduction of isiXhosa as a medium of instruction at this ...
Dalvit, Lorenzo
core   +2 more sources

From mother tongue to English: A language policy shift at a multilingual township school in Gauteng

open access: yesSouth African Journal of Childhood Education
Background: Given the lack of research into English language instruction in multilingual contexts, this study explored the switch from mother tongue to English in a South African township school. Aim: This study aims to find out how teachers and parents
Rockie Sibanda, Lina P. Tshehla
doaj   +1 more source

Teacher Targets: A model for CLIL and ELF teacher education in polytechnic settings [PDF]

open access: yes, 2013
The objective of this paper is to present an alternative model for CLIL/ELF teacher education, called the Teacher Target Model, which may help hard-science teachers undertake English-medium instruction more efficiently.
Sancho Guinda, Carmen
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Towards a synthesis of multimedia and intelligent tutoring systems : a dissertation presented in partial fulfilment of the requirements for the degree of Master of Science in Computer Science at Massey University [PDF]

open access: yes, 1998
Multimedia is being used in almost every field. This study is about the use of multimedia in the area of intelligent tutoring systems. This project studies the advantages and disadvantages of interactive multimedia and intelligent tutoring systems, and ...
Vethanayagam, Emma A. K
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The Medium of Instruction Policy in Nepal: Towards Critical Engagement on the Ideological and Pedagogical Debate

open access: yesJournal of Language and Education, 2019
Although there were attempts to develop multilingual and multicultural education in Nepal, changes have remained more discursive than pragmatic at the working level. Problems discussed have remained unsolved. The issues of protection and promotion of the
Prem Prasad Poudel
doaj   +1 more source

Delay Line as a Chemical Reaction Network [PDF]

open access: yes, 2015
Chemistry as an unconventional computing medium presently lacks a systematic approach to gather, store, and sort data over time. To build more complicated systems in chemistries, the ability to look at data in the past would be a valuable tool to perform
Banda, Peter   +2 more
core   +3 more sources

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