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Clinical Oncology, 2013 Medulloblastomas are primary malignant embryonal tumours of the central nervous system. They are the most common childhood central nervous system tumour, but are rare in the adult population. They arise infratentorially in the cerebellum or fourth ventricle and hence the most common presenting symptoms are those associated with raised intracranial ...
Yusra Sheikh
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Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma [PDF]
Translational Oncology, 2019 A subset of poor-prognosis medulloblastoma has genomic amplification of MYC. MYC regulates glutamine metabolism in multiple cellular contexts.
Allison R. Hanaford +9 more
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Oxamate, but Not Selective Targeting of LDH-A, Inhibits Medulloblastoma Cell Glycolysis, Growth and Motility [PDF]
Brain Sciences, 2018 Medulloblastoma is the most common malignant paediatric brain tumour and current therapies often leave patients with severe neurological disabilities.
Cara J. Valvona, Helen L. Fillmore
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Adult desmoplastic medulloblastoma
Saudi Journal of Medicine and Medical Sciences, 2017 Medulloblastoma is more common in young age and rare in adult age. Some characteristics that characterize medulloblastoma in adults compared with children: Lateral cerebellar location, heterogeneous signal intensity on magnetic resonance imaging ...
Abdulrahman H Al Anazi +3 more
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Nature Reviews Disease Primers, 2019 Under the term embryonal tumours, we examine the malignant neoplasms medulloblastomas, CNS-PNETs, AT/RTs, and ETANTRs. The common histological link between them is the small, round, blue cells which appear on H&E stains. They are considered highly malignant tumours (WHO Grade IV), although significant variation of prognosis exists between the ...
Paul A, Northcott +11 more
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Paediatric desmoplastic medulloblastoma – Surgical treatment, adjuvant therapy, outcome survival (case series study) [PDF]
Romanian Journal of Neurology, 2020 Background. Desmoplastic medulloblastoma is a common adult cerebellar tumor. It has better than classic medulloblastoma outcome. This is a case series study followed up the cases of paediatric desmoplastic medulloblastoma and their treatment outcome and
Raad Ahmed Hussein +3 more
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RBM5-AS1 promotes radioresistance in medulloblastoma through stabilization of SIRT6 protein
Acta Neuropathologica Communications, 2021 Cancer stem cells (CSCs) contribute to radioresistance in medulloblastoma. Thus, identification of key regulators of medulloblastoma stemness is critical for improving radiotherapy for medulloblastoma.
Chuanying Zhu +3 more
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Analysis of risk factors of medulloblastoma recurrence based on the molecular subgroups
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 Objective To investigate the recurrence rate and risk factors for the patients with medulloblastoma based on the molecular subgroups. Methods A retrospective study was conducted for the clinicopathological data of 67 medulloblastoma patients who were ...
LIU Hai⁃long +7 more
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iScience, 2023 Summary: We show that inactivating AMPK in a genetic medulloblastoma model depletes tumor stem cells and slows progression. In medulloblastoma, the most common malignant pediatric brain tumor, drug-resistant stem cells co-exist with transit-amplifying ...
Daniel Shiloh Malawsky +7 more
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Journal of Child Neurology, 2016 Medulloblastoma accounts for nearly 10% of all childhood brain tumors. These tumors occur exclusively in the posterior fossa and have the potential for leptomeningeal spread. Treatment includes a combination of surgery, radiation therapy (in patients >3 years old).
Nathan E, Millard, Kevin C, De Braganca
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