PRMT1 is an important factor for medulloblastoma cell proliferation and survival
Biochemistry and Biophysics Reports, 2022 Aberrant expression of protein arginine methyltransferases (PRMTs) has been implicated in a number of brain tumors, but the role of PRMT1 in medulloblastoma, the most common malignant pediatric brain tumor, remains unexplored.
Xiao Gu +8 more
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Medulloblastoma has a global impact on health related quality of life: Findings from an international cohort [PDF]
, 2020 BACKGROUND: Understanding the global impact of medulloblastoma on health related quality of life (HRQL) is critical to characterizing the broad impact of this disease and realizing the benefits of modern treatments.
de Medeiros, Cynthia B +2 more
core +8 more sources
Analytical Cellular Pathology, 2022 Medulloblastoma is one of the most common malignant tumors of the central nervous system in children. Although KIF2B was reported as an oncogene in several malignant tumor types, its role in medulloblastoma has not been studied so far. The PCR results of
Yajun Liu +6 more
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Anomalous vascularization in a Wnt medulloblastoma: A case report [PDF]
, 2016 BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature.
Cacchione, Antonella +11 more
core +2 more sources
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. [PDF]
, 2017 SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane ...
Bufalieri, Francesca +18 more
core +8 more sources
Gene expression analyses of the spatio-temporal relationships of human medulloblastoma subgroups during early human neurogenesis. [PDF]
PLoS ONE, 2014 Medulloblastoma is the most common form of malignant paediatric brain tumour and is the leading cause of childhood cancer related mortality. The four molecular subgroups of medulloblastoma that have been identified - WNT, SHH, Group 3 and Group 4 - have ...
Cornelia M Hooper +4 more
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MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence. [PDF]
PLoS ONE, 2010 MicroRNAs (miRNAs) are a class of short non-coding RNAs that regulate cell homeostasis by inhibiting translation or degrading mRNA of target genes, and thereby can act as tumor suppressor genes or oncogenes.
Sujatha Venkataraman +5 more
doaj +1 more source
BET bromodomain protein inhibition is a therapeutic option for medulloblastoma [PDF]
, 2013 Medulloblastoma is the most common malignant brain tumor of childhood, and represents a significant clinical challenge in pediatric oncology, since overall survival currently remains under 70%.
Althof, Kristina +13 more
core +4 more sources
Machine Learning Decision Tree Models for Differentiation of Posterior Fossa Tumors Using Diffusion Histogram Analysis and Structural MRI Findings. [PDF]
, 2020 We applied machine learning algorithms for differentiation of posterior fossa tumors using apparent diffusion coefficient (ADC) histogram analysis and structural MRI findings.
Aboian, Mariam +3 more
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Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth
BMC Cancer, 2011 Background Medulloblastoma is the most common brain tumor in children, and its prognosis is worse than for many other common pediatric cancers. Survivors undergoing treatment suffer from serious therapy-related side effects.
Olson James M +5 more
doaj +1 more source