Results 21 to 30 of about 71,273 (273)

Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma [PDF]

, 2010
Background The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer.
Afzal, Mohammad, Castresana, Javier S, Eberhart, Charles G., Fan, Xing, Rey, Juan A, Shahi, Mehdi H, Sinha, Subrata   +6 more
core   +5 more sources

Medulloblastomas

Neurosurgery Clinics of North America, 1990
It is obvious that the past decade has witnessed considerable progress in the management of children with medulloblastoma. Better surgical technique has led to more aggressive surgery with less morbidity. The use of staging has led to reduction in radiation therapy doses in some patients and will, it is hoped, lead to better neuropsychological outcome.
L N, Sutton, R J, Packer, L, Schut
openaire   +2 more sources

Metastatic Medulloblastoma [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1974
SUMMARY:The incidence of metastatic medulloblastoma is probably greater than the thirteen documented patients. Case reports of metastatic medulloblastoma must be carefully analysed. We have added two cases which conform to Weiss’ criteria for metastatic disease. The direction and factors influencing spread have been discussed.
D, Parkinson, R T, Ross, C B, Shields
openaire   +2 more sources

Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

BMC Cancer, 2019
Background MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associated with aberrant MYC function in ...
Nagendra K. Chaturvedi, Sidharth Mahapatra, Varun Kesherwani, Matthew J. Kling, Mamta Shukla, Sutapa Ray, Ranjana Kanchan, Naveenkumar Perumal, Timothy R. McGuire, J. Graham Sharp, Shantaram S. Joshi, Don W. Coulter   +11 more
doaj   +1 more source

Delta-catenin attenuates medulloblastoma cell invasion by targeting EMT pathway

Frontiers in Genetics, 2022
Background: Medulloblastoma is the most common pediatric malignant tumor in central nervous system. Although its prognosis has been improved enormously by the combination treatments with surgery, radiotherapy, and chemotherapy, it still could progress ...
Yuanjun Hu, Yuanjun Hu, Yuanjun Hu, Sihan Zhu, Sihan Zhu, Rizhen Xu, Manxia Wang, Furong Chen, Zeshun Zhang, Binghong Feng, Jian Wang, Zhongping Chen, Zhongping Chen, Jing Wang, Jing Wang   +14 more
doaj   +1 more source

Molecular subgroups of adult medulloblastoma: a long-term single-institution study [PDF]

, 2016
Background Recent transcriptomic approaches have demonstrated that there are at least 4 distinct subgroups in medulloblastoma (MB); however, survival studies of molecular subgroups in adult MB have been inconclusive because of small sample sizes. The aim
Ai, Lin, GIANGASPERO, FELICE, Li, Chunde, Li, Peng, Liu, Pinan, Luo, Lin, Ohgaki, Hiroko, Wang, Bo, Wang, Xingchao, Wang, Zhenmin, Xu, Lei, Yang, Zhijun, Zhang, Jing, Zhao, Fu   +13 more
core   +1 more source

Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era

Frontiers in Oncology, 2020
Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes.
Roberto Carta, Giada Del Baldo, Evelina Miele, Agnese Po, Zein Mersini Besharat, Francesca Nazio, Giovanna Stefania Colafati, Eleonora Piccirilli, Emanuele Agolini, Martina Rinelli, Mariachiara Lodi, Antonella Cacchione, Andrea Carai, Luigi Boccuto, Luigi Boccuto, Elisabetta Ferretti, Franco Locatelli, Franco Locatelli, Angela Mastronuzzi   +18 more
doaj   +1 more source

Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma

Scientific Reports, 2023
VAMP (Vesicle-associated membrane protein)-associated protein B and C (VAPB) has been widely studied in neurodegenerative diseases such as ALS, but little is known about its role in cancer.
Amanda Faria Assoni, Thiago Giove Mitsugi, René Wardenaar, Raiane Oliveira Ferreira, Elisa Helena Farias Jandrey, Gabriela Machado Novaes, Isabela Fonseca de Oliveira Granha, Petra Bakker, Carolini Kaid, Mayana Zatz, Floris Foijer, Oswaldo Keith Okamoto   +11 more
doaj   +1 more source

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells [PDF]

, 2018
Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development.
Agnese Po, Andrea Carai, Angela Mastronuzzi, Elisabetta Ferretti, Elisabetta Ferretti, Enrico De Smaele, Evelina Miele, Felice Giangaspero, Felice Giangaspero, Franco Locatelli, Franco Locatelli, Luana Abballe, Marta Moretti, Zein Mersini Besharat   +13 more
core   +9 more sources

Disseminated medulloblastoma in a child with germline BRCA2 6174delT mutation and without Fanconi anemia

Frontiers in Oncology, 2015
Medulloblastoma, the most common malignant brain tumor in children, occurs with increased frequency in individuals with Fanconi anemia who have biallelic germline mutations in BRCA2.
Jingying eXu, Ashley Sloane Margol, Ashley Sloane Margol, Anju eShukla, Xiuhai eRen, Jonathan L Finlay, Jonathan L Finlay, Mark D Krieger, Mark D Krieger, Floyd H Gilles, Floyd H Gilles, Fergus J Couch, Meraj eAziz, Eric T Fung, Shahab eAsgharzadeh, Shahab eAsgharzadeh, Michael T Barrett, Anat eErdreich-Epstein, Anat eErdreich-Epstein   +18 more
doaj   +1 more source