Results 31 to 40 of about 71,273 (273)

Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature

Case Reports in Pathology, 2020
Medulloblastoma is an embryonal neuroepithelial tumor that affects mainly childhood and more rarely adults. Medulloblastoma occurring as multiple nodules at diagnosis is a rare and tricky presentation.
Irene Troncon, Angela Guerriero, Sabrina Rossi, Monica Ronzon, Marta Padovan, Caccese Mario, Lucia Zanatta, Luisa Toffolatti, Elisabetta Marton, Giuseppe Lombardi, Angelo Paolo Dei Tos, Giuseppe Canova   +11 more
doaj   +1 more source

Rare cases of medulloblastoma with hypermutation

Cancer Reports, 2022
Background Medulloblastoma is the most common malignant brain tumor of childhood and is considered a tumor with low mutational burden (~1 Mut/Mb). Therefore, though the medulloblastoma genomes have been extensively characterized in literature, reports on
Aditi Bagchi, Ian Beddows, Albert Cornelius, Giles W. Robinson, Scott D. Jewell   +4 more
doaj   +1 more source

Organ-specific low-dose assessment in pediatric radiotherapy using nanodot OSL and NTCP modeling: Application to medulloblastoma. [PDF]

J Appl Clin Med Phys
Abstract Background In pediatric radiotherapy, controlling low‐dose exposure is a major challenge, particularly in the treatment of medulloblastoma, where the long life expectancy of young patients makes optimization of radioprotection crucial. Purpose This study provides a comprehensive and quantitative assessment of low‐dose exposure to normal ...
Tantaoui M, Krim M, Chehab F, Essaidi EM, Mesradi MR, Kartouni A, Sahraoui S.   +6 more
europepmc   +2 more sources

A high-throughput screening identifies histone deacetylase inhibitors as therapeutic agents against medulloblastoma

Experimental Hematology & Oncology, 2019
Background Medulloblastoma is the most frequently occurring malignant brain tumor in children. Current treatment strategies for medulloblastoma include aggressive surgery, cranio-spinal irradiation and adjuvant chemotherapy.
Shanshan Zhang, Zhaojian Gong, Peter O. Oladimeji, Duane G. Currier, Qipan Deng, Ming Liu, Taosheng Chen, Yong Li   +7 more
doaj   +1 more source

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. [PDF]

, 2019
Dysregulation of the seven-transmembrane (7TM) receptor Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway contributes to the development of cancers including basal cell carcinoma (BCC) and medulloblastoma (MB).
Abagyan, Ruben, Chahal, Kirti Kandhwal, Chen, Clark C, Durden, Donald L, Kufareva, Irina, Li, Jie, Parle, Milind, Wechsler-Reya, Robert J   +7 more
core   +1 more source

A molecular biology and phase II trial of lapatinib in children with refractory CNS malignancies: a pediatric brain tumor consortium study. [PDF]

, 2013
High expression of ERBB2 has been reported in medulloblastoma and ependymoma; EGFR is amplified and over-expressed in brainstem glioma suggesting these proteins as potential therapeutic targets. We conducted a molecular biology (MB) and phase II study to
Blaney, Susan M., Boyett, James M., Fouladi, Maryam, Gajjar, Amar, Geyer, J. Rusell, Gilbertson, Richard J., Goldman, Stewart, Kun, Larry E., Onar Thomas, Arzu, Packer, Roger J., Schaiquevich, Paula Susana, Stewart, Clinton F.   +11 more
core   +1 more source

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. [PDF]

, 2015
Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, and patients who survive ...
Berezov, A, Brun, SN, Conway, EM, Crawford, JR, Esparza, LA, Garcia, G, Grant, GA, Greene, MI, Huang, J-M, Levy, ML, Li, X-N, Markant, SL, Nakano, I, Pavlyukov, MS, Smith, LH, Terry, D, Wang, Q, Wechsler-Reya, RJ   +17 more
core   +2 more sources

Posterior fossa extra-axial variations of medulloblastoma: a pictorial review as a primer for radiologists

Insights into Imaging, 2021
Manifestations of an atypical variant of medulloblastoma of the posterior fossa in extra-axial locations have been reported, and key questions concerning its interpretation have been raised previously. This review illustrated the clinico-radiological and
Abdulaziz M. Al-Sharydah, Abdulrahman Hamad Al-Abdulwahhab, Sari Saleh Al-Suhibani, Wisam M. Al-Issawi, Faisal Al-Zahrani, Faisal Ahmad Katbi, Moath Abdullah Al-Thuneyyan, Tarek Jallul, Faisal Mishaal Alabbas   +8 more
doaj   +1 more source

Low apparent diffusion coefficient in an extracranial brain tumor: a case report

Journal of Medical Case Reports, 2022
Background Medulloblastoma is well known as the most common malignant brain tumor identified in children, frequently found at an intra-axial location in the posterior cranial fossa. Extra-axial medulloblastoma is uncommon and often misdiagnosed.
Ho Xuan Tuan, Nguyen Duy Hung, Nguyen Dinh Minh, Nguyen Nhat Quang, Ngo Quang Duy, Nguyen Minh Duc   +5 more
doaj   +1 more source

LLL12B, a small molecule STAT3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells

Scientific Reports, 2021
Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor and an oncogene product, which plays a pivotal role in tumor progression.
Xiang Chen, Li Pan, Jia Wei, Ruijie Zhang, Xiaozhi Yang, Jinhua Song, Ren-Yuan Bai, Shengling Fu, Christopher R. Pierson, Jonathan L. Finlay, Chenglong Li, Jiayuh Lin   +11 more
doaj   +1 more source