Results 51 to 60 of about 71,273 (273)
A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth [PDF]
, 2019 Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1)
Balducci, Silvia +14 more
core +1 more source
Pediatric Hematology and Oncology, 1998 Medulloblastomas account for 20% of all primary brain tumors. The vast majority of them are sporadic. Familial medulloblastoma is very rare--only a few cases have been reported worldwide. Most were observed in siblings of the same sex. The affected children presented at various ages and all of them have died, usually within the first 2 years following ...
Moschovi, M +6 more
openaire +3 more sources
Extra-axial Cerebellopontine Angle Adult Medulloblastoma: An Unusual Presentation at an Unusual Site
Indian Journal of Neurosurgery, 2019 Medulloblastoma is a rare adult primary brain tumor and its presence in the cerebellopontine angle (CPA) constitutes an even rarer site for origin. There are only 40 reported cases of CPA medulloblastoma in the literature, with most being intra-axial and
Vishwaraj Ratha +2 more
doaj +1 more source
Turning off the switch in medulloblastoma. The inhibitory acetylation of an oncogene [PDF]
, 2010 [No abstract ...
CANETTIERI, Gianluca +4 more
core +1 more source
Medulloblastoma with extensive nodularity (SHH medulloblastoma) [PDF]
Polish Journal of Pathology, 2017 Medulloblastoma is the most common CNS embryonal tumor and the most common malignant tumor of childhood. Its overall incidence is 1.8 cases per 1 million people, with a childhood incidence of 6 cases per 1 million. 77 percent of patients are less than 19 years old.
Iga Alicja, Fudyma, Nitin R, Wadhwani
openaire +2 more sources
Posterior fossa medulloblastoma in an atypical extra-axial location: A case report
Radiology Case Reports, 2018 Medulloblastoma is the most common posterior fossa tumor of childhood typically within the fourth ventricle. However, extra-axial medulloblastoma in posterior fossa is an uncommon diagnosis.
Elizabeth Presutto, BS +3 more
doaj +1 more source
Albumin nanoparticles for glutathione-responsive release of cisplatin: new opportunities for medulloblastoma treatment [PDF]
, 2016 Redox-responsive nanoparticles were synthesized by desolvation of bovine serum albumin followed by disulfide-bond crosslinking with N, Nʹ-Bis (acryloyl) cystamine. Dynamic light scattering and transmission electron microscopy studies revealed spherical
Abballe, Luana +9 more
core +1 more source
Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine. [PDF]
, 2016 Children with aggressive neural tumors have poor survival rates and novel therapies are needed. Previous studies have identified nifurtimox and buthionine sulfoximine (BSO) as effective agents in children with neuroblastoma and medulloblastoma.
Du, Michael +4 more
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Tumor-Associated Macrophages Correlate With Prognosis in Medulloblastoma
Frontiers in Oncology, 2022 PurposeMacrophage polarization plays an essential role in the tumor microenvironment of brain tumors. However, the role of tumor-associated macrophages (TAMs) in medulloblastoma still remains controversial.
Jin Zhang +13 more
doaj +1 more source