Results 171 to 180 of about 27,974 (255)

Altered cytoskeletal integrity underlies impaired platelet shape change and defective thrombus formation in ETV6‐related thrombocytopenia

British Journal of Haematology, Volume 208, Issue 6, Page 1965-1979, June 2026.
Summary ETV6‐related thrombocytopenia (ETV6‐RT) is an inherited platelet disorder caused by germline ETV6 variants. Despite recent progress, the mechanisms underlying platelet dysfunction in ETV6‐RT remain unclear. We investigated 12 patients from six families using functional assays, electron microscopy, quantitative proteomics and cytoskeletal ...
Ivan P. Tesakov, Julia‐Jessica D. Korobkin, Daria V. Fedorova, Sofia V. Galkina, Maria M. Golomysova, Sergei I. Obydennyi, Anastasia A. Ignatova, Ekaterina‐Iva A. Adamanskaya, Eugenia V. Yushkova, Anna V. Pavlova, Pavel A. Zharkov, Igor I. Kireev, Galina A. Novichkova, Viktor G. Zgoda, Mikhail A. Panteleev, Anastasia N. Sveshnikova   +15 more
wiley   +1 more source

Exploring the Impact of Adjuvants on Vaccine Immunity Through Hematopoietic Cells. [PDF]

Vaccines (Basel)
Ji Y, Bekkari K, Shardar M, Walford GA, Kim S, Liu Y, Read-Button W, Tracy K, Kriss J, Barr C, Wolfle M, Kummar S, LaPorta C, Graham R, Chen L, Smith WJ, Bakshi K, Murgolo N, Sullivan NL.   +18 more
europepmc   +1 more source

Integrated proteomic and metabolomic profiling reveals sex‐stratified biomarkers predicting chronicity in paediatric primary immune thrombocytopenia

British Journal of Haematology, Volume 208, Issue 6, Page 1954-1964, June 2026.
Construction of the immune thrombocytopenia (ITP) chronicity prediction model was based on sex‐stratified multi‐omics analysis, identifying key sex‐specific predictors (intercellular adhesion molecule‐1 [ICAM‐1] and biopterin in males; actin, alpha 2, smooth muscle, aorta [ACTA‐2] and N6‐acetyl‐L‐lysine in females).
Yuanyuan Xue, Rongrong Zhang, Dongmei Liang, Yupeng Xu, Zhaofang Tian, Xiaohong Dai, Wei Xu, Qingqing Cao, Haiyan Zhu, Yun Wang, Yufang Yuan   +10 more
wiley   +1 more source

Real‐world treatment patterns and outcomes among patients with immune thrombocytopenia (ITP) who switched treatment from eltrombopag or romiplostim to avatrombopag in the United States: Results from the REAL‐AVA 3.5 study

British Journal of Haematology, Volume 208, Issue 6, Page 2185-2193, June 2026.
Summary Real‐world data on treatment response after switching between thrombopoietin receptor agonists are limited for patients with immune thrombocytopenia (ITP). The objective of this study is to describe treatment patterns and outcomes in patients with primary ITP who switched from eltrombopag (ELT) or romiplostim (ROMI) to avatrombopag (AVA).
Caroline Piatek, Abiola Oladapo, Scott Kolodny, Michael Vredenburg, Sarah Lucht, Emily Bland, Prathamesh Pathak, Bruce Feinberg, Hillary Maitland   +8 more
wiley   +1 more source

Hematopoietic Niche Hijacking in Bone Metastases: Roles of Megakaryocytes, Erythroid Lineage Cells, and Perivascular Stromal Subsets. [PDF]

Biomedicines
Alkhatib AR, Elshimy Y, Atassi B, Mohammad KS.   +3 more
europepmc   +1 more source

Eltrombopag Combined With Cyclosporine A in the Treatment of Pediatric Patients With SAA: Establishing the Range for Eltrombopag Concentrations

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Eltrombopag (ELT), as an oral thrombopoietin receptor agonist, in combination with cyclosporine A (CsA) provides a novel therapeutic option for pediatric severe aplastic anemia (SAA). However, current clinical protocols predominantly adopt fixed‐dose regimens without adequate consideration of pediatric pharmacokinetic characteristics and drug ...
Fashuang Li, Na Li, Xiaoling Tang, Tilong Huang, Linbo Li, Huiying Li, Danyang Ren, Caixia Tu, Dan Li   +8 more
wiley   +1 more source

Identification of a novel nonsense mutation (c.1369 C > T) in the WAS gene in a neonate: a case report and literature review. [PDF]

BMC Pediatr
Deng S, Liu X, Chen S, Wan L, Dong W, Kang L.   +5 more
europepmc   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, Volume 293, Issue 12, Page 3502-3527, June 2026.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Integrated single-cell transcriptomic analysis identifies <i>PF4</i> ^<i>+</i> <i>/PPBP</i> ^<i>+</i> megakaryocyte-like granulocytes associated with immune dysregulation in autoimmune diseases. [PDF]

Biochem Biophys Rep
Chen S, Fan Y, Su M, Lin Y, Zheng S, Zhou Z, Zhang W, Lin J, Hu S, Matucci-Cerinic M, Furst DE, Zhang G, Wang Y.   +12 more
europepmc   +1 more source

Hematopathology Practice in the Digital Era: What has Changed?

International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 503-511, June 2026.
ABSTRACT Hematopathology workflows are complex, since they include numerous data points necessary for guiding further testing, diagnosis, and patient management. The workflows start with complete blood cell counts, with subsequent morphologic evaluation of peripheral blood (PB) and bone marrow (BM).
Olga Pozdnyakova
wiley   +1 more source