Results 181 to 190 of about 34,194 (287)

Menin-dependent megakaryocyte proliferation and fibrosis in myeloproliferative neoplasms. [PDF]

Cancer Cell
Wen J, Cotton A, Mehmood R, Mohan M, Hall T, Broadhurst AL, Zhang K, Olufadi Y, Kang G, Marcellino B, Mascarenhas J, Hoffman R, Janke LJ, Gurbuxani S, McGeehan GM, Crispino JD.   +15 more
europepmc   +1 more source

Hematopoietic JAK2V617F mutation-induced reprogramming of blood and bone marrow megakaryocytes. [PDF]

Blood Adv
Lu S, Karkempetzaki AI, Huang N, Zhang C, Murphy GJ, Ravid K.   +5 more
europepmc   +1 more source

Dissecting Bone Marrow Fibrosis in Philadelphia-Negative Myeloproliferative Neoplasms: Multiple Roads Lead to Rome. [PDF]

Hematol Oncol
Ballato M, Fiorentino V, Ricciardi G, Tralongo P, Germanà E, Allegra A, Stagno F, Fadda G, Martini M.   +8 more
europepmc   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

The thrombopoietin receptor S264F mutant drives MPN with marrow fibrosis through a dual mechanism

HemaSphere, Volume 10, Issue 10, October 2026.
Charlotte Lees, Emile Brandt, Emmanuel Dutranoix, Gabriel Levy, Bogdan I. Iorga, Hosuk Ryou, Jens Rittscher, Daniel Royston, Stefan N. Constantinescu, Adam J. Mead   +9 more
wiley   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

Acute Megakaryocytic Leukemia [PDF]

Mayo Clinic Proceedings, 1989
openaire   +2 more sources

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

MedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source

Case Report: Hereditary thrombotic thrombocytopenic purpura mimicking immune thrombocytopenia: diagnostic pitfalls of whole-exome sequencing. [PDF]

Front Pediatr
Xie N, He Y, Wu D.
europepmc   +1 more source