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VEXAS syndrome: more than just vacuoles. [PDF]
Hematol Transfus Cell TherBarros Pinto MP.
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2023
Megakaryocytes are commonly known as large, polyploid, bone marrow resident cells that contribute to hemostasis through the production of platelets. Soon after their discovery in the 19th century, megakaryocytes were described in tissue locations other than the bone marrow, specifically in the lungs and the blood circulation.
Florian Puhm +2 more
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Megakaryocytes are commonly known as large, polyploid, bone marrow resident cells that contribute to hemostasis through the production of platelets. Soon after their discovery in the 19th century, megakaryocytes were described in tissue locations other than the bone marrow, specifically in the lungs and the blood circulation.
Florian Puhm +2 more
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Megakaryocyte and polyploidization
Experimental Hematology, 2018In mammals, platelets are produced in the blood by cytoplasmic fragmentation of megakaryocytes (MKs). Platelet production is thus dependent on both the MK number and size. During differentiation, MKs switch from a division by mitosis to polyploidization by endomitosis to increase their size. The endomitotic process includes several successive rounds of
Stefania, Mazzi +4 more
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Megakaryocytes in pulmonary diseases
Life Sciences, 2022Megakaryocytes (MKs) are typical cellular components in the circulating blood flowing from the heart into the lungs. Physiologically, MKs function as an important regulator of platelet production and immunoregulation. However, dysfunction in MKs is considered a trigger in various diseases.
Di-Yun, Huang +6 more
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Megakaryocytes and Megakaryocyte Progenitors in Human Cord Blood
Journal of Pediatric Hematology/Oncology, 1992Thrombocytopenia contributes significantly to morbidity in the sick term or preterm infant. However, few data exist on newborn's megakaryocytes and megakaryocyte progenitor cells (CFU-MK). We therefore studied CFU-MK in term and preterm infant cord blood and compared the results with data on CFU-MK from adult bone marrow and adult peripheral blood in a
T A, Olson +4 more
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Journal of Cellular Physiology, 1982
AbstractAn assay describing conditions for the maturation of single immature megakaryocytes in vitro is reported. Enriched populations of small, relatively immature megakaryocytes have been found to develop into single, mature megakaryocytes by 60 hours in semisolid agar cultures.
Long, M W, Williams, N, Mcdonald, T P
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AbstractAn assay describing conditions for the maturation of single immature megakaryocytes in vitro is reported. Enriched populations of small, relatively immature megakaryocytes have been found to develop into single, mature megakaryocytes by 60 hours in semisolid agar cultures.
Long, M W, Williams, N, Mcdonald, T P
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Histopathology, 1982
Cells resembling the smaller variants of the Warthin‐Finkeldey giant cells of measles were observed in the pulmonary alveolar capillaries in a high percentage of primates and humans apparently free from pathological changes associated with measles. Cells resembling megakaryocytes were found also in the liver and spleen in both groups but only in a ...
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Cells resembling the smaller variants of the Warthin‐Finkeldey giant cells of measles were observed in the pulmonary alveolar capillaries in a high percentage of primates and humans apparently free from pathological changes associated with measles. Cells resembling megakaryocytes were found also in the liver and spleen in both groups but only in a ...
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Blood, 2010
In this issue of Blood, Halene and colleagues reveal an essential function of the transcription factor SRF during megakaryocyte maturation and platelet formation. The spectrum of SRF-regulated genes overlaps with SRF targets in muscle cells, including those involved in actin cytoskeletal dynamics.
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In this issue of Blood, Halene and colleagues reveal an essential function of the transcription factor SRF during megakaryocyte maturation and platelet formation. The spectrum of SRF-regulated genes overlaps with SRF targets in muscle cells, including those involved in actin cytoskeletal dynamics.
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Megakaryocytic Myelosis in a Cat
Journal of the American Veterinary Medical Association, 1976SUMMARY A myeloproliferative disorder in a cat was characterized by abnormal proliferation of megakaryocytes in the bone marrow and by severe, nonregenerative anemia. The number of circulating thrombocytes was increased markedly, with many giant and morphologically bizarre forms.
R L, Michel, P, O'Handley, A W, Dade
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