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Case Report: Persistent severe thrombocytopenia after adjuvant ado-trastuzumab emtansine with sequential bone marrow findings and romiplostim support. [PDF]

Front Oncol
Qiao D, Nie L, Liu S, Ding HB.
europepmc   +1 more source

Assessing bleeding risk by thromboelastography when automated platelet count fails due to giant platelets. [PDF]

Blood Vessel Thromb Hemost
Ye Z, Sami F, Hinojosa O, Zheng L, Gu H, Zhao X, Dasgupta A, Zheng XL.   +7 more
europepmc   +1 more source

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Diversity of Megakaryocytes

Arteriosclerosis, Thrombosis, and Vascular Biology, 2023
Megakaryocytes are commonly known as large, polyploid, bone marrow resident cells that contribute to hemostasis through the production of platelets. Soon after their discovery in the 19th century, megakaryocytes were described in tissue locations other than the bone marrow, specifically in the lungs and the blood circulation.
Florian Puhm, Éric Boilard, Audree Laroche   +2 more
exaly   +3 more sources

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

Blood, 2013
Megakaryocytes give rise to platelets via extension of proplatelet arms, which are released through the vascular sinusoids into the bloodstream. Megakaryocytes and their precursors undergo varying interactions with the extracellular environment in the ...
Gareth E. Jones, Steven G. Thomas
exaly   +2 more sources

Megakaryocyte and polyploidization

Experimental Hematology, 2018
In mammals, platelets are produced in the blood by cytoplasmic fragmentation of megakaryocytes (MKs). Platelet production is thus dependent on both the MK number and size. During differentiation, MKs switch from a division by mitosis to polyploidization by endomitosis to increase their size. The endomitotic process includes several successive rounds of
Mazzi, Stefania, Lordier, Larissa, Debili, Najet, Raslova, Hana, Vainchenker, William   +4 more
openaire   +3 more sources

Megakaryocytes and Megakaryocyte Progenitors in Human Cord Blood

Journal of Pediatric Hematology/Oncology, 1992
Thrombocytopenia contributes significantly to morbidity in the sick term or preterm infant. However, few data exist on newborn's megakaryocytes and megakaryocyte progenitor cells (CFU-MK). We therefore studied CFU-MK in term and preterm infant cord blood and compared the results with data on CFU-MK from adult bone marrow and adult peripheral blood in a
T A, Olson, R F, Levine, E M, Mazur, D G, Wright, A J, Salvado   +4 more
openaire   +2 more sources