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Systems Biology of Megakaryocytes

2014
The molecular pathways that regulate megakaryocyte production have historically been identified through multiple candidate gene approaches. Several transcription factors critical for generating megakaryocytes were identified by promoter analysis of megakaryocyte-specific genes, and their biological roles then verified by gene knockout studies; for ...
Alexis, Kaushansky, Kenneth, Kaushansky
openaire   +2 more sources

Immunological face of megakaryocytes

Frontiers of Medicine
Megakaryocytes (MKs), which are traditionally known for their role in platelet production, are now emerging as unique immune cells with diverse capabilities. They express immune receptors, participate in pathogen recognition and response, phagocytose pathogens, contribute to antigen presentation, and interact with various immune cell types.
Yueying, Li   +2 more
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[Megakaryocytic leukemia cell lines and megakaryocytic leukemia].

Rinsho byori. The Japanese journal of clinical pathology, 1990
Using the megakaryocytic leukemia cell lines, K-562 and CMK established from a Down's patient with acute megakaryoblastic leukemia, we studied the changes of antigen expression, cytosolic Ca2+ mobilization, thromboxane (TX) A2 formation and gene expression during megakaryocyte differentiation. We found that thrombospondin synthesis and platelet factor (
R, Ryo, A, Yoshida, N, Yamaguchi
openaire   +1 more source

Circulating megakaryocytes

Histopathology, 1983
D, Slater, J, Martin, A, Trowbridge
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Megakaryocyte podography

Veterinary Clinical Pathology, 2009
Michael A, Scott, Kristen R, Friedrichs
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Megakaryocytes and atherosclerosis

Clinical Science, 1992
S D, Kristensen, J F, Martin
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Decoding Human Megakaryocyte Development

Cell Stem Cell, 2021
Lihong Shi, Mengge Wang, Yu Lan
exaly  

MicroRNA Profiling of Megakaryocytes

2009
MiRNAs are non-coding RNAs of 19-25 nucleotides in length that regulate gene expression. Recent work suggests a role for miRNAs during hematopoiesis. Here, we described in detail how to successfully obtain highly pure megakaryocytes precursors from human CD34+ stem cells in culture to perform high-throughput miRNA profiling using a custom microarray ...
openaire   +2 more sources

The Role of Megakaryocytes in Myelofibrosis

Hematology/Oncology Clinics of North America, 2021
Anna Rita Migliaccio   +2 more
exaly  

Dysplastic Megakaryocytes

ASH Image Bank, 2004
openaire   +1 more source

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