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Systems Biology of Megakaryocytes
2014The molecular pathways that regulate megakaryocyte production have historically been identified through multiple candidate gene approaches. Several transcription factors critical for generating megakaryocytes were identified by promoter analysis of megakaryocyte-specific genes, and their biological roles then verified by gene knockout studies; for ...
Alexis, Kaushansky, Kenneth, Kaushansky
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Immunological face of megakaryocytes
Frontiers of MedicineMegakaryocytes (MKs), which are traditionally known for their role in platelet production, are now emerging as unique immune cells with diverse capabilities. They express immune receptors, participate in pathogen recognition and response, phagocytose pathogens, contribute to antigen presentation, and interact with various immune cell types.
Yueying, Li +2 more
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[Megakaryocytic leukemia cell lines and megakaryocytic leukemia].
Rinsho byori. The Japanese journal of clinical pathology, 1990Using the megakaryocytic leukemia cell lines, K-562 and CMK established from a Down's patient with acute megakaryoblastic leukemia, we studied the changes of antigen expression, cytosolic Ca2+ mobilization, thromboxane (TX) A2 formation and gene expression during megakaryocyte differentiation. We found that thrombospondin synthesis and platelet factor (
R, Ryo, A, Yoshida, N, Yamaguchi
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Megakaryocytes and atherosclerosis
Clinical Science, 1992S D, Kristensen, J F, Martin
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MicroRNA Profiling of Megakaryocytes
2009MiRNAs are non-coding RNAs of 19-25 nucleotides in length that regulate gene expression. Recent work suggests a role for miRNAs during hematopoiesis. Here, we described in detail how to successfully obtain highly pure megakaryocytes precursors from human CD34+ stem cells in culture to perform high-throughput miRNA profiling using a custom microarray ...
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The Role of Megakaryocytes in Myelofibrosis
Hematology/Oncology Clinics of North America, 2021Anna Rita Migliaccio +2 more
exaly

