Results 161 to 170 of about 27,974 (255)

<i>In vitro</i> derivation of megakaryocytes and platelets from induced pluripotent stem cells: developmental foundations and translational perspectives. [PDF]

Front Immunol
Mazurek M, Młynarski W, Grzela DP.
europepmc   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

MPIG6B-related thrombocytopenia and myelofibrosis: A case report. [PDF]

Ann Hematol
Wang X, Xue F, Zhang L, Yang R.
europepmc   +1 more source

Calreticulin Type 26 Mutation in Myelofibrosis: A Rare Variant With Diagnostic Challenges

Journal of Clinical Laboratory Analysis, Volume 40, Issue 11, June 2026.
ABSTRACT Background Myeloproliferative neoplasms (MPNs) are clonal hematologic disorders commonly driven by mutations in JAK2, MPL, or CALR. Because routine CALR assays are largely optimized for the canonical Type 1 and Type 2 exon 9 variants, rare noncanonical mutations may be missed, creating diagnostic challenges.
Teresa Maltese, Giuseppina Raffa, Fabio Stagno, Rossana Leanza, Paola Barone, Alessandro Allegra, Teresa Pollicino   +6 more
wiley   +1 more source

Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche. [PDF]

Elife
Masson C, Scandola C, Rinckel JY, Proamer F, Janus-Bell E, Batool F, Osmani N, Goetz JG, Mallo L, Brouard N, Leon C, Bornert A, Poincloux R, Destaing O, Mansson A, Qian H, Lehmann M, Eckly A.   +17 more
europepmc   +1 more source

Reticulated Platelets and an Optimal Model for Differentiating Thrombocytopenia Etiologies

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Objectives This study aimed to investigate the clinical value of reticulated platelets (RtcPLT) percentage derived from an automated hematology analyzer in differentiating thrombocytopenia due to peripheral etiology from decreased bone marrow production (BME). In addition, a secondary objective was to establish specific reference intervals for
Tung Thanh Tran, Quyen Ngoc Truong, Hong Phuoc Mac, Thang Thanh Phan, Tai Chau Quach, Son Truong Nguyen   +5 more
wiley   +1 more source

Si xian formula (SXF) alleviates carboplatin-induced bone marrow microenvironment damage and promotes thrombocytopenia recovery by regulating gut microbiota and bone marrow metabolites: a correlative study. [PDF]

Front Pharmacol
Li F, Yu MY, Jiang N, Yao MY, Xu XY, He LM, Zhou Z, Luo X.   +7 more
europepmc   +1 more source

Relaxation Time Mapping of Early‐Stage Osteonecrosis of the Femoral Head: An In Vivo Piglet Model Study

Journal of Orthopaedic Research, Volume 44, Issue 6, June 2026.
T2, T1ρ, adiabatic T1ρ, and adiabatic T2ρ relaxation time mapping techniques are sensitive in detecting ischemic injury to bone marrow of the femoral head in vivo in a piglet model at 3 T MRI. T2 and adiabatic T2ρ relaxation times have the most pronounced increase in ischemic versus perfused, contralateral‐control femoral heads 1 week after induction ...
Casey P. Johnson, Erick O. Buko, Sampada Bhave, Kayla L. Chase, Douglas Albrecht, Alexandra R. Armstrong, Jutta M. Ellermann, Harry K. W. Kim, Ferenc Tóth   +8 more
wiley   +1 more source

A Case Report of Shwachman‐Diamond Syndrome Caused by Heterozygous Variants in the EFL1 Gene and Literature Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.
We report a neonatal SDS patient with earliest onset of symptoms. The c.2935C>T and c.3149_3151delCAC compound heterozygous variants reported in this study expand the mutational spectrum of this disease. ABSTRACT Objective This investigation reports on a Shwachman‐Diamond syndrome (SDS) case arising from compound heterozygous genetic variations ...
Xiaoying Zhou, Hongxin Li, Xinyi Yang, Chunli Wang, Wenting Zhang   +4 more
wiley   +1 more source

Mitochondria regulate the cell fate decisions of megakaryocyte-erythroid progenitors. [PDF]

Stem Cell Reports
Sung E, Murakami S, Morita M, Ida T, Akaike T, Motohashi H.   +5 more
europepmc   +1 more source