Results 101 to 110 of about 8,227 (218)

A comparison of haematopoietic stem cells from umbilical cord blood and peripheral blood for platelet production in a microfluidic device [PDF]

, 2019
Background and objectives: Several sources of haematopoietic stem cells have been used for static culture of megakaryocytes to produce platelets in vitro.
Baruch, Dominique, Compernolle, Veerle, Devloo, Rosalie, Feys, Hendrik, Sicot, Geraldine, Six, Katrijn   +5 more
core   +1 more source

Thrombocytopenia and disseminated histoplasmosis in immunocompetent adults [PDF]

, 2017
Disseminated histoplasmosis among immunocompetent patients is rare, but may be associated with clinically significant refractory thrombocytopenia. Platelet counts often return to normal levels following antifungal therapy.
Czader, Magdalena, Fulkerson, Zachary, Goldman, Mitchell, Kutkut, Issa, Mehta, Rakesh, Swenberg, Jessica, Vater, Laura   +6 more
core   +2 more sources

Utility and Safety of Romiplostim in Pediatric Allogeneic Stem Cell Transplantation

Pediatric Transplantation, Volume 29, Issue 8, December 2025.
ABSTRACT Background The use of romiplostim, a thrombopoietin agonist, has increased in the last decade for the treatment of immune mediated thrombocytopenia and severe aplastic anemia. Its utility has been explored in the management of delayed platelet engraftment and secondary platelet failure during stem cell transplant (SCT), but its use has ...
Srividhya Senthil, Abdul Moothedath, Jane Elizabeth Potter, Heather Mcgrath Wilkinson, Eden Whiteside, Ramya Nataraj, Omima Mustafa, Claire Horgan, Denise Bonney, Sarah Brett, Rob Wynn   +10 more
wiley   +1 more source

A Rare Hematopoietic Stem Cell‐Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging

Aging Cell, Volume 24, Issue 11, November 2025.
Manso et al. developed strategies for isolating and testing the functional mechanisms regulating age‐specific megakaryocyte progenitors derived from hematopoietic stem cells. ABSTRACT Distinct routes of cellular production from hematopoietic stem cells (HSCs) have defined our current view of hematopoiesis.
Bryce A. Manso, Paloma Medina, Stephanie Smith‐Berdan, Alessandra Rodriguez y Baena, Elmira Bachinsky, Lydia Mok, Angela Deguzman, Sarah Beth Avila, Connor Van Voorhis, Saran Chattopadhyaya, Marcel G. E. Rommel, Jenna Myers, Vanessa D. Jönsson, E. Camilla Forsberg   +13 more
wiley   +1 more source

Two patients with acute thrombocytopenia following gold administration and five-year follow-up [PDF]

, 2003
Thrombocytopenia is a well-known side effect following intramuscular gold therapy in patients with rheumatoid arthritis. Thrombocytopenia may occur at any time and it can be irreversible and sometimes fatal despite cytotoxic or ...
Levin, M.-D. (Mark-David), Markusse, H.M., Veer, M.B. (Mars) van 't, Veld, J.C. de   +3 more
core   +1 more source

Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data [PDF]

, 2012
BACKGROUND AND OBJECTIVES: Although several studies demonstrated that platelet count is higher in women, decreases with age, and is influenced by genetic background, most clinical laboratories still use the reference interval 150-400×10(9) platelets/L ...
Balduini, CL, Biino, G, Cerletti, C, Ciullo, M, De Gaetano, G, Di Castelnuovo, A, Francavilla, M, Frongia, B, Gasparini, P, Gögele, M, Iacoviello, L, Minelli, C, Nutile, T, Pirastu, M, Pirastu, N, Pramstaller, P, Sala, C, Santimone, I, Sorice, R, Toniolo, D, Traglia, M, Ulivi, S   +21 more
core   +1 more source

Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy [PDF]

, 2014
Histone deacetylase (HDAC)-inhibitors (HDACis) are well characterized anti-cancer agents with promising results in clinical trials. However, mechanistically little is known regarding their selectivity in killing malignant cells while sparing normal cells.
Behrens, Georg M.N., Bourquin, Jean-Pierre, Heitmann, Kirsten, Khatib, Mona El, Klusmann, Jan-Henning, Leverkus, Martin, Li, Zhe, Orkin, Stuart H., Panayotova-Dimitrova, Diana, Reinhardt, Dirk, Schoening, Jennifer, Schweitzer, Nora, Stankov, Metodi V., Thakur, Basant Kumar, Welte, Karl   +14 more
core   +1 more source

High-Efficiency Enrichment of Megakaryocytes and Identification of Micromegakaryocytes from Human Bone Marrow by Imaging Flow Cytometry

Cells
Megakaryocytes (MKs) are rare, large, polyploid bone marrow (BM) cells responsible for the production of platelets. The identification and characterization of MKs is widely recognized as challenging.
Maya Nautrup Pedersen, Trine Engelbrecht Hybel, Jens Haugbølle Bjerre, Anne Sofie Borg Hammer, Anja Bille Bohn, Marie Bill, Carina Agerbo Rosenberg, Maja Ludvigsen   +7 more
doaj   +1 more source

C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation

Cell Communication and Signaling, 2018
Background Megakaryopoiesis allows platelet formation, which is necessary for coagulation, also playing an important role in different pathologies. However, this process remains to be fully characterized. C3G, an activator of Rap1 GTPases, is involved in
Sara Ortiz-Rivero, Cristina Baquero, Luis Hernández-Cano, Juan José Roldán-Etcheverry, Sara Gutiérrez-Herrero, Cristina Fernández-Infante, Víctor Martín-Granado, Eduardo Anguita, José María de Pereda, Almudena Porras, Carmen Guerrero   +10 more
doaj   +1 more source

Persistent immune stimulation exacerbates genetically driven myeloproliferative disorders via stromal remodeling [PDF]

, 2017
Systemic immune stimulation has been associated with increased risk of myeloid malignancies, but the pathogenic link is unknown. We demonstrate in animal models that experimental systemic immune activation alters the bone marrow stromal microenvironment,
Botti, Laura, Burocchi, Alessia, Cappetti, Barbara, Chiodoni, Claudia, Colombo, Mario P., Falini, Brunangelo, Gulino, Alessandro, Isidori, Alessandro, Liso, Arcangelo, Martelli, Maria Paola, Pandolfi, Pier Paolo, Piccaluga, Pier Paolo, Portararo, Paola, Sangaletti, Sabina, Tripodo, Claudio, Visani, Giuseppe   +15 more
core   +1 more source