Results 181 to 190 of about 8,227 (218)

Neonatal and adult megakaryopoiesis

Current Opinion in Hematology, 2011
It has become increasingly clear that there are substantial biological differences between fetal/neonatal and adult megakaryopoiesis. Over the last 18 months, studies challenged the paradigm that neonatal megakaryocytes are immature and revealed a developmentally unique uncoupling of proliferation, polyploidization, and cytoplasmic maturation.
Zhi-Jian, Liu, Martha, Sola-Visner
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Molecular mechanisms of megakaryopoiesis

Cellular and Molecular Life Sciences, 2006
One function of bone marrow megakaryocytes (MKs) is the controlled release of platelets into the circulation. Over the past few years, molecular mechanisms that contribute to MK development and differentiation have begun to be elucidated. This review provides a brief overview of megakaryopoiesis and platelet function, and the importance of selected ...
G, Szalai, A C, LaRue, D K, Watson
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Interferon-γ and Human Megakaryopoiesis

Leukemia & Lymphoma, 1998
Interferon-gamma (IFN-gamma) exhibits various properties including antigrowth activity in neoplastic and normal cells and regulatory roles in immune responses and hematopoiesis, but studies of IFN-gamma effects on human megakaryopoiesis have been inconclusive.
K, Tsuji, K, Muraoka, T, Nakahata
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Megakaryopoiesis disturbances in atherosclerotic rabbits

Atherosclerosis, 1987
Rabbits given a hypercholesterolemic diet (500 mg/day) for 6 months and then maintained for another 6 months on a normal diet were found to have developed fibrous lipidic lesions in the aorta. Although circulating platelet levels in these animals were normal there was a reduction in mean megakaryocyte ploidy.
H, Dupont, M A, Dupont, J, Larrue, M R, Boisseau, H, Bricaud   +4 more
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Megakaryopoiesis: Transcriptional Insights into Megakaryocyte Maturation

Frontiers in Bioscience, 2007
Platelets are small anucleate cells that travel near the vessel wall during laminar flow. In response to vascular injury, platelets undergo alterations in morphology which allow them to aggregate and cover the injured site. Platelets are produced by megakaryocytes in a process that involves the formation of platelet precursors called proplatelets and ...
John Creigh, Kostyak, Ulhas Pandurang, Naik   +1 more
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Megakaryopoiesis in patients with cyclic thrombocytopenia

British Journal of Haematology, 1995
Summary Megakaryopoiesis was examined in 10 patients (eight females and two males) with cyclic thrombocytopenia (CT) to investigate the underlying pathogenesis. Numbers of CFU‐Meg and megakaryocytes and the mean cytoplasmic area (mean area) of megakaryocytes at the peak, nadir, ascent mid phase, and descent mid phase of the platelet cycle were ...
T, Nagasawa, Y, Hasegawa, M, Kamoshita, K, Ohtani, T, Komeno, T, Itoh, A, Shinagawa, H, Kojima, H, Ninomiya, T, Abe   +9 more
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BUBR1 deficiency results in abnormal megakaryopoiesis

Blood, 2003
The physiologic function of BUBR1, a key component of the spindle checkpoint, was examined by generating BUBR1-mutant mice. BUBR1(-/-) embryos failed to survive beyond day 8.5 in utero as a result of extensive apoptosis. Whereas BUBR1(+/-) blastocysts grew relatively normally in vitro, BUBR1(-/-) blastocysts exhibited impaired proliferation and ...
Qi, Wang, Tongyi, Liu, Yuqiang, Fang, Suqing, Xie, Xuan, Huang, Radma, Mahmood, Gita, Ramaswamy, Kathleen M, Sakamoto, Zbigniew, Darzynkiewicz, Ming, Xu, Wei, Dai   +10 more
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Molecular Control of Megakaryopoiesis and Thrombopoiesis

International Journal of Hematology, 2002
Megakaryopoiesis and subsequent thrombopoiesis occur through complex biologic steps: megakaryocyte precursors that developed from hematopoietic stem cells initially proliferate, then differentiate into mature polyploid megakaryocytes, and finally release platelets.
Itaru, Matsumura, Yuzuru, Kanakura
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Megakaryopoiesis and Thrombopoiesis

2017
Platelets are formed from the cytoplasm of megakaryocytes (MKs) that reside in the bone marrow (BM). MKs arise from hematopoietic stem cells in the osteoblastic niche in BM. The primary regulator of megakaryopoiesis is thrombopoietin. It is generally accepted that MKs migrate into the vascular niche and produce platelets; however, the mechanism by ...
Shugo Kowata, Yoji Ishida
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Direct megakaryopoiesis

Current Opinion in Hematology
Purpose of review Megakaryocytes are large, polyploid cells that produce platelets and originate from hematopoietic stem cells (HSCs) in the bone marrow. While in the classical paradigm, megakaryocytes are generated in a stepwise fashion through increasingly committed progenitor stages, studies using in-vivo barcoding ...
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