Results 71 to 80 of about 5,890 (202)

Leishmaniasis in Morocco: Epidemiology, Transmission Dynamics, and the Potential of Artificial Intelligence for Disease Management

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Leishmaniases are neglected tropical diseases caused by Leishmania parasites and transmitted by infected phlebotomine sand flies, and they remain a major public health challenge in Morocco. The burden is dominated by cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL), mainly associated with Leishmania major, Leishmania tropica, and L ...
Chaymaa Harkat, Denis Sereno, Abdelmohcine Aimrane, Moulay Abdelmonaim Hidan, Mohamed El Yamani, Kholoud Kahime, Satabdi Datta Choudhury   +6 more
wiley   +1 more source

Simplified decision tree model for the analyses of the cost-effectiveness of intralesional infiltration, in comparison with parenteral use of meglumine antimoniate, in the treatment of cutaneous leishmaniasis.

, 2019
IL-MA: meglumine antimoniate intralesional infiltration; EV-MA: endovenous meglumine antimoniate therapy; p_adverse eventes_IL: probability of adverse events during IL-MA; p_adverse eventes_EV: probability of adverse events during during EV-MA; cure_SIST:
Nayara C. Brito (8087945), Ana Rabello (112015), Gláucia Cota (4679719), Tália S. Machado de Assis (8087948)   +3 more
core   +1 more source

Evaluation of the IC₅₀ values of azacitidine and meglumine antimoniate against amastigotes and promastigotes forms of Leishmania. major, compared to meglumine antimoniate and CC₅₀ values of the drugs on macrophages using the SI index.

, 2023
Evaluation of the IC50 values of azacitidine and meglumine antimoniate against amastigotes and promastigotes forms of Leishmania. major, compared to meglumine antimoniate and CC50 values of the drugs on macrophages using the SI index.
Mahdieh Lashkarizadeh (16955395), Alireza Keyhani (4960432), Ali Derakhshani (14349240), Setareh Agha Kuchak Afshari (16955389), Mehdi Bamorovat (4836909), Behzad Iranmanesh (16955392), Ehsan Salarkia (6831890), Moslem Lari Najafi (9752033), Hamid Nejad Biglari (16955398), Iraj Sharifi (344800)   +9 more
core   +1 more source

Evidence Gaps and Global Patterns in Leishmaniasis Control: A Scoping Review of Clinical, Diagnostic, and Treatment Strategies

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Background Leishmaniasis is a neglected tropical disease with diverse clinical forms, heterogeneous geographical distribution, and persistent diagnostic and treatment challenges. Although substantial primary research exists, evidence remains fragmented, limiting integrated and context‐specific control strategies.
Muhi-deen Wonwana Mohammed, Yussif Owusu Aboagye, Akwasi Anyanful, Samuel Kyei, Kwame Kumi Asare, Pengfei Cai   +5 more
wiley   +1 more source

Leishmania RNA Virus and Its Impact on Drug Response and Clinical Outcomes in Leishmaniasis: A Comprehensive Review

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Leishmania RNA viruses (LRVs) have emerged as significant modulators of disease severity, therapeutic response, and clinical outcomes in various forms of leishmaniasis. This review provides a comprehensive overview of the current knowledge surrounding LRV1 and LRV2, focusing on their taxonomy, molecular biology, epidemiological patterns, and pathogenic
Azadeh Zolfaghari, Sarah Seyedyousefi, Zabihollah Shahmoradi, Erfan Zaker, Bahman Rahimi Esboei, Amit Prasad   +5 more
wiley   +1 more source

The Safety and Efficacy of an Immunomodulator Garlic‐Based Cream (LeishG1) for Treating Uncomplicated Cutaneous Leishmaniasis: A Single‐Blind, Multi‐Center Study

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Cutaneous leishmaniasis (CL) is a major problem in developing nations, particularly in the Middle East. Novel herbal treatment options may provide a safe alternative associated with favorable outcomes in CL lesion healing.
Fatemeh Emadi, Zohreh Khodashenas, Azadeh Rashidi, Ali Khamesipour, Mehdi Zaboli, Mehri Ghafourian, Mohammad Mehdi Naghizadeh, Fatemeh Tuserkani, Tooba Ghazanfari   +8 more
wiley   +1 more source

Mitochondrial Dysfunction Induced by a Novel Salicylate‐Based 1,2,3‐Triazole Salt With Potent Antileishmanial Activity

Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.
A novel salicylate‐based 1,2,3‐triazole salt was synthesized and demonstrated potent and selective activity against Leishmania amazonensis. The most active compound induced mitochondrial dysfunction without hemolytic effects. In silico analyses also suggested favorable pharmacokinetic properties and oral bioavailability.
Bruno A. De Oliveira, Ari Sérgio de Oliveira Lemos, João Pedro Reis Costa Bastos, Luciana Maria Ribeiro Antinarelli, Ana Luiza Ribeiro de Freitas, Raissa Guedes Mattosinhos Ribeiro, Adolfo Firmino da Silva Neto, Elaine Soares Coimbra, Adilson David Da Silva   +8 more
wiley   +1 more source

The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Current treatment of cutaneous leishmaniasis includes pentavalent antimonials as first-line drugs, but this therapy has shown severe adverse effects. An alternative to minimize this issue is based on combination therapy scheme with other drugs.
Luiz Filipe Gonçalves-Oliveira, Ph.D., Franklin Souza-Silva, Ph.D., Luzia Monteiro de Castro Côrtes, Ph.D., Laura Barral Veloso, Ph.D., Bernardo Acácio Santini Pereira, Ph.D., Lea Cysne-Finkelstein, Ph.D., Guilherme Curty Lechuga, Ph.D., Saulo Cabral Bourguignon, Ph.D., Fernando Almeida-Souza, Ph.D., Kátia da Silva Calabrese, Ph.D., Vitor Francisco Ferreira, Ph.D., Carlos Roberto Alves, Ph.D.   +11 more
doaj   +1 more source

Associated-risk determinants for anthroponotic cutaneous leishmaniasis patients treated by intramuscular meglumine antimoniate alone.

, 2019
Associated-risk determinants for anthroponotic cutaneous leishmaniasis patients treated by intramuscular meglumine antimoniate alone.
Fatemeh Sharifi (3496619), Rajender S. Varma (1407823), Mohammad Reza Aflatoonian (525156), Hamid Sharifi (525162), Mehdi Mohebali (62368), Mehrdad Khatami (6831896), Nasir Arefinia (6831899), Mohammad Mehdi Gouya (572523), Pooya Ghasemi Nejad Almani (4960441), Ahmad Khosravi (525161), Amireh Heshmatkhah (4960435), Saeideh Farajzadeh (6831905), Alireza Fekri (6831902), Ali Khamesipour (62371), Behnaz Aflatoonian (525159), Abbas Aghaei Afshar (6831893), Mehdi Bamorovat (4836909), Zahra Babaei (806332), Ehsan Salarkia (6831890), Mohammad Reza Shirzadi (3092862), Mohammad Ali Mohammadi (4960429), Iraj Sharifi (344800)   +21 more
core   +1 more source

The effect of different concentrations of azacitidine and meglumine antimoniate on the mean number of intra-macrophage amastigotes.

, 2023
The effect of different concentrations of azacitidine and meglumine antimoniate on the mean number of intra-macrophage amastigotes.
Mahdieh Lashkarizadeh (16955395), Alireza Keyhani (4960432), Ali Derakhshani (14349240), Setareh Agha Kuchak Afshari (16955389), Mehdi Bamorovat (4836909), Behzad Iranmanesh (16955392), Ehsan Salarkia (6831890), Moslem Lari Najafi (9752033), Hamid Nejad Biglari (16955398), Iraj Sharifi (344800)   +9 more
core   +1 more source