Results 51 to 60 of about 2,191 (109)

Complete Resolution of Cutaneous Leishmaniasis With a Novel Topical Combination Therapy: A Case Series

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Cutaneous leishmaniasis (CL) remains a therapeutic challenge in endemic regions, with 600,000–1 million new cases annually facing limited treatment options. We present a case series evaluating an innovative topical combination therapy for acute‐phase CL in Shiraz, Iran.
Hoda Haghshenas, Aref Ghanaatpisheh, Mohammad Darayesh, Elaheh Entezar Almahdi   +3 more
wiley   +1 more source

The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Current treatment of cutaneous leishmaniasis includes pentavalent antimonials as first-line drugs, but this therapy has shown severe adverse effects. An alternative to minimize this issue is based on combination therapy scheme with other drugs.
Luiz Filipe Gonçalves-Oliveira, Ph.D., Franklin Souza-Silva, Ph.D., Luzia Monteiro de Castro Côrtes, Ph.D., Laura Barral Veloso, Ph.D., Bernardo Acácio Santini Pereira, Ph.D., Lea Cysne-Finkelstein, Ph.D., Guilherme Curty Lechuga, Ph.D., Saulo Cabral Bourguignon, Ph.D., Fernando Almeida-Souza, Ph.D., Kátia da Silva Calabrese, Ph.D., Vitor Francisco Ferreira, Ph.D., Carlos Roberto Alves, Ph.D.   +11 more
doaj   +1 more source

Efficacy and Safety of Topical Dapsone in Dermatology: A Scoping Review of Clinical Studies

Journal of Cosmetic Dermatology, Volume 24, Issue 10, October 2025.
ABSTRACT Background Dapsone (4,4′‐Diamino diphenyl sulfone) has been utilized in managing a wide variety of mucocutaneous conditions, usually as a systemic product. Topical dapsone is commercially available as 5% and 7.5% gel and is FDA‐approved for acne vulgaris.
Bahareh Abtahi‐Naeini, Hossein Sattari, Kimia Afshar, Fereshte Rastegarnasab, Mahsa Pourmahdi‐Boroujeni   +4 more
wiley   +1 more source

Green Propolis Extract‐Mediated Synthesis of Biogenic Silver Nanoparticles: In Vitro Antileishmanial and Antibacterial Activities, Cytotoxicity and Ex Vivo Irritation Testing

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT This study describes the green synthesis, characterization, and biological evaluation of silver nanoparticles (AgNPs) obtained from green propolis (AgNPs‐PRO). Before nanoparticles synthesis, a hydroethanolic green propolis extract (GPE) was obtained through ultrasound‐assisted extraction and characterized by high‐performance liquid ...
Erica Tirzah S. Lima, Victoria L. S. Santos, Wanessa J. S. Mota, Frederico S. Martins, Ricardo L. C. de Albuquerque‐Junior, André L. S. Santos, Simone S. C. Oliveira, Jéssica A. de Lima, Adriana de Jesus Santos, Cochiran P. dos Santos, Sona Jain, Eliana B. Souto, Juliana C. Cardoso, Patrícia Severino   +13 more
wiley   +1 more source

Long-term follow-up of dogs with leishmaniosis treated with meglumine antimoniate plus allopurinol versus miltefosine plus allopurinol

Parasites & Vectors, 2015
Background Visceral leishmaniosis is a potentially life-threatening illness caused by a protozoan parasite of the genus Leishmania. It is found mainly in areas where both the parasite and its vector are endemic and is one of the most challenging ...
Laura Manna, Raffaele Corso, Giorgio Galiero, Anna Cerrone, Paolo Muzj, Angelo Elio Gravino   +5 more
doaj   +1 more source

First Report on Infant Acute Urticaria after Mother’s Parenteral Use of Meglumine Antimoniate (Glucantime): A Case Report

Iranian Journal of Public Health, 2016
Pentavalent antimonials are still the first drug of choice for the treatment of cutaneous leishmaniasis (CL). Like other treatments, they can cause adverse reactions including musculoskeletal pain, gastrointestinal disturbances, and mild to moderate ...
Omid MOZAFARI, Seyed Afshin SHOROFI, Seyde Sedighe YOUSEFI   +2 more
doaj  

High frequency of skin reactions in patients with leishmaniasis treated with meglumine antimoniate contaminated with heavy metals: a comparative approach using historical controls

Memorias do Instituto Oswaldo Cruz, 2003
We analyzed data from historical controls treated with meglumine antimoniate to compare the frequency of adverse events observed in patients with cutaneous leishmaniasis treated with the same dose of meglumine antimoniate contaminated with heavy metals ...
Gustavo Adolfo Sierra Romero, Érico Marlon de Moraes Flores, Elza Ferreira Noronha, Vanize de Oliveira Macêdo   +3 more
doaj   +1 more source

LEUCOGRAMA E METABOLISMO OXIDATIVO DOS NEUTRÓFILOS DE CÃES COM LEISHMANIOSE VISCERAL ANTES E APÓS O TRATAMENTO COM ANTIMONIATO DE MEGLUMINA E ALOPURINOL

Ciência Animal Brasileira, 2010
Leukogram and neutrophil oxidative metabolism fromdogs with visceral leishmaniasis (VL) were compared before andafter treatment with meglumine antimoniate (AM) and with anassociation of meglumine antimoniate and allopurinol (AMA).The results obtained ...
Paulo César Ciarlini, Taiana Carvalho Valadares, Fabiana Augusta Ikeda-Garcia, Mary Marcondes, Valéria Marçal Félix de Lima   +4 more
doaj  

Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update.

PLoS ONE, 2013
IntroductionLeishmaniasis is an important public health problem in the Americas. A Cochrane review published in 2009 analyzed 38 randomized controlled trials (RCT). We conducted a systematic review to evaluate the effects of therapeutic interventions for
Ludovic Reveiz, Ana Nilce Silveira Maia-Elkhoury, Rubén Santiago Nicholls, Gustavo Adolfo Sierra Romero, Zaida E Yadon   +4 more
doaj   +1 more source

Granulomatous rhinitis secondary to feline leishmaniosis: report of an unusual presentation and therapeutic complications

Journal of Feline Medicine and Surgery Open Reports, 2018
Case summary A 12-year-old male neutered domestic shorthair cat underwent rhinoscopy due to inspiratory dyspnoea and stertor. Rhinoscopy showed signs of chronic rhinitis and a multinodular nasopharyngeal mucosa.
Rodolfo Oliveira Leal, Hugo Pereira, Clara Cartaxeiro, Esmeralda Delgado, Maria da Conceição Peleteiro, Isabel Pereira da Fonseca   +5 more
doaj   +1 more source