Results 41 to 50 of about 5,890 (202)

Diet and leishmaniasis in the Ecuadorian Amazon

Medical Anthropology Quarterly, EarlyView.
Abstract In Ecuador's Amazon, Indigenous communities affected by leishmaniasis often modify their diets as part of their health‐seeking practices. Drawing on qualitative research with sixty‐eight participants from seven Indigenous groups, this study explores how and why patients’ diets shift in pursuit of healing from leishmaniasis.
Veronica Cristina Vargas Roman
wiley   +1 more source

Combined suboptimal schedules of topical paromomycin, meglumine antimoniate and miltefosine to treat experimental infection caused byLeishmania(Viannia)braziliensis [PDF]

, 2015
Objectives: This study aimed to evaluate the efficacy of binary combinations of suboptimal schedules of drugs with different administration routes (topical paromomycin, intramuscular meglumine antimoniate and oral miltefosine) to treat animals infected ...
Eliane de Morais-Teixeira, Aguiar, Marta Gontijo, Marta Gontijo Aguiar, Lucas Antônio Miranda Ferreira, Bruna Soares de Souza Lima, Rabello, Ana Lucia Teles, Teixeira, Eliane de Morais, Lima, Bruna Soares de Souza, Ferreira, Lucas Antonio Miranda, Ana Rabello   +9 more
core   +1 more source

Antileishmanial Activity of 2-Methoxy-4H-spiro-[naphthalene-1,2′-oxiran]-4-one (Epoxymethoxy-lawsone): A Promising New Drug Candidate for Leishmaniasis Treatment

Molecules, 2018
Epoxymethoxylawsone is a naphthoquinone derivative promising as drug candidate for the treatment of leishmaniases. In the present work the effectiveness of epoxymethoxylawsone, and meglumine antimoniate on Leishmania (Leishmania) amazonensis parasites ...
Luiz Filipe Gonçalves Oliveira, Franklin Souza-Silva, Luzia Monteiro de Castro Côrtes, Lea Cysne-Finkelstein, Mirian Cláudia de Souza Pereira, Francisco Odêncio de Oliveira Junior, Rosa Teixeira Pinho, Suzana Corte Real, Saulo Cabral Bourguignon, Vitor Francisco Ferreira, Carlos Roberto Alves   +10 more
doaj   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Comparison of in vitro Resistance of Wild Leishmania İsolates, Which are Resistant to Pentavalent Antimonial Compounds, Against Drugs Used in the Treatment of Leishmaniasis

Türkiye Parazitoloji Dergisi, 2020
Objective:Meglumine antimoniate (Glucantime®) and Sodium stibogluconate (Pentostam®) are used for the treatment of cutaneous leismaniasis in Turkey. There is a reported resistance to these drugs in recent years.
Ahmet Özbilgin, İbrahim Çavuş, Tuğba Kaya, Ahmet Yıldırım, Mehmet Harman   +4 more
doaj   +1 more source

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

Characterization of the Antimonial Antileishmanial Agent Meglumine Antimonate (Glucantime) [PDF]

Antimicrobial Agents and Chemotherapy, 1998
ABSTRACT Meglumine antimonate (Glucantime), a drug of choice for the treatment of leishmaniasis, is produced by the reaction of pentavalent antimony with N -methyl- d -glucamine, a carbohydrate derivative.
W L, Roberts, W J, McMurray, P M, Rainey
openaire   +2 more sources

Good response to pentamidine isethionate in a case of Mucosal Leishmaniasis caused by Leishmania (Viannia) braziliensis that was difficult to treat: Case Report

Revista da Sociedade Brasileira de Medicina Tropical, 2019
In Brazil, meglumine antimoniate is the first drug of choice for mucosal leishmaniasis treatment followed by amphotericin B and pentamidine isethionate.
Benivaldo Ramos Ferreira Terceiro, Tania Salgado de Souza Torraca, Frederico Pereira Bom Braga, Ana Cristina da Costa Martins, Lucia Regina Brahim, Mauricio Naoto Saheki, Luciana de Freitas Campos Miranda, Armando de Oliveira Schubach, Cláudia Maria Valete-Rosalino   +8 more
doaj   +1 more source

Clinical and Diagnostic Considerations in Laryngeal Leishmaniasis: A Systematic Review

OTO Open, Volume 10, Issue 3, July-September 2026.
Abstract Objective Laryngeal leishmaniasis is a rare, insidious manifestation of Leishmania infection with potential for life‐threatening complications. Awareness is critical for efficient and timely diagnosis. This systematic review of laryngeal leishmaniasis focuses on presentation, treatment, and the role of serological studies in the work up of ...
Joseph Celidonio, Nicholas Hamilton, Alexandra Filipkowski, Raj Malhotra, Samantha Shave, Myat E. Mon, Kenneth Yan, Rachel Kaye   +7 more
wiley   +1 more source

Ex vivo host and parasite response to antileishmanial drugs and immunomodulators. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Therapeutic response in infectious disease involves host as well as microbial determinants. Because the immune and inflammatory response to Leishmania (Viannia) species defines the outcome of infection and efficacy of treatment ...
Laura Gonzalez-Fajardo, Olga Lucía Fernández, Diane McMahon-Pratt, Nancy Gore Saravia   +3 more
doaj   +1 more source